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Our lab performs basic & translational research to understand the role of monocytes and macrophages in modulating airway inflammation in people with cystic fibrosis (CF).


Lab Resources & Services

The lab is located on National Jewish Health main campus.


Current Projects

  1. Characterization of macrophage populations in the CF airway, and investigations into how these cells modulate inflammation.

    • How much heterogeneity is present in airway macrophage populations?

    • Does the abundance of populations of macrophage shift during pulmonary exacerbations?

    • How do various medications affect airway macrophages phenotypes?

  2. Identification of novel therapeutics / anti-inflammatory medications for people with CF (and other chronic inflammatory airways diseases)

  3. Investigations into the role of macrophages in susceptibility of people with CF to NTM infection.


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Katherine Hisert

Katherine Hisert, MD, PhD


Principal Investigator:
Katherine “Katie” Hisert, MD, PhD
Research Technicians
Alma Ochoa
Jack Congel

Postdoctoral Fellow
Jodi Corley, PhD






  • Carter SC, Franciosi AN, O'Shea KM, O'Carroll OM, Sharma A, Bell A, Keogan B, O'Reilly P, Coughlan S, Law SM, Gray RD, Hisert KB, Singh PK, Cooke G, Grogan B, De Gascun CF, Gallagher CG, Nicholson TT, Quon BS, McKone EF. Acute Pulmonary Exacerbation Phenotypes in Patients with Cystic Fibrosis. Ann Am Thorac Soc. 2022 Nov;19(11):1818-1826. doi: 10.1513/AnnalsATS.202111-1266OC. PubMed PMID: 35713619; PubMed Central PMCID: PMC9667812.

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