Our lab studies how mesenchymal progenitor cells (MPC) regulate lung microvascular function and dysregulated angiogenesis as well as how these processes contribute to the development or severity of chronic lung diseases (including fibrosis, emphysema as well as pulmonary hypertension).
Lab Resources and Services
The Majka lab has identified and characterized a novel population of lung mesenchymal progenitor cells (MPC) as a regulator of microvascular function, structure and homeostasis. Her lab has developed techniques to isolate, differentiate and analyze murine and human mesenchymal stem cell phenotype, proliferation, inflammation, migration and matrix synthesis both in vitro and in vivo. To complement in vivo models of disease the laboratory has developed a method for mesenchymal, endothelial and smooth muscle differentiation of murine and human iPS cells.