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McCubbrey Lab

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Our lab studies the roles of phagocytes during lung injury and repair. View Our Current Projects

We are happy to discuss opportunities for research collaboration.

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Repair after injury is a fundamental biologic process that is essential for lung health. Our lab studies the role of phagocytes and phagocytosis during tissue repair. We explore how the different types of “meals” engulfed by phagocytes uniquely impact phagocyte function. In particular, we are interested in how engulfment of apoptotic cells is able to prime phagocytes for repair. We are also working to understand the heterogeneity of lung phagocytes, particularly macrophages, and describe their locations and functions following lung injury.


Current Projects



Alexandra McCubbrey

Alexandra McCubbrey, PhD

lab diagram

McCubbrey AL, McManus SA, McClendon JD, Thomas SM, Chatwin HB, Reisz JA, D'Alessandro A, Mould KJ, Bratton DL, Henson PM, Janssen WJ. Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells. Cell Rep. 2022 Jan 11;38(2):110222. PMID: 35021097

lab diagram 2

McCubbrey AL, Barthel L, Mohning MP, Redente EF, Mould KJ, Thomas SM, Leach SM, Danhorn T, Gibbings SL, Jakubzick CV, Henson PM, Janssen WJ. Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis. Am J Respir Cell Mol Biol. 2018 Jan;58(1):66-78. PMID: 28850249 

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Lab Personnel

Alexandra McCubbrey, PhD
Assistant Professor

Peter Moore, MD

Shannon Hott
Lab Researcher Technician

Hope Chatwin
Lab Researcher Technician

View Collaborators

Contact Us

The McCubbrey Lab is located on the main National Jewish Health campus.

Interested labs should contact Alexandra McCubbrey to discuss opportunities for research collaboration.


Job Opportunities

Postdoctoral researchers seeking to study phagocyte responses to apoptotic cells should contact Alexandra McCubbrey to discuss position availability.