Skip to content

McCubbrey Lab

McCubbrey labs banner

Our lab studies the roles of phagocytes during lung injury and repair. View Our Current Projects

We are happy to discuss opportunities for research collaboration.

Contact Us

Repair after injury is a fundamental biologic process that is essential for lung health. Our lab studies the role of phagocytes and phagocytosis during tissue repair. We explore how the different types of “meals” engulfed by phagocytes uniquely impact phagocyte function. In particular, we are interested in how engulfment of apoptotic cells and other cell corpses is able to prime phagocytes for repair. We are also working to understand the heterogeneity of lung phagocytes, particularly macrophages, and describe their locations and functions following lung injury.


Current Projects



Alexandra McCubbrey

Alexandra McCubbrey, PhD

lab diagram

McCubbrey AL, McManus SA, McClendon JD, Thomas SM, Chatwin HB, Reisz JA, D'Alessandro A, Mould KJ, Bratton DL, Henson PM, Janssen WJ. Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells. Cell Rep. 2022 Jan 11;38(2):110222. PMID: 35021097

Moore PK, Anderson KC, McManus SA, Tu TH, King EM, Mould KJ, Redente EF, Henson PM, Janssen WJ, McCubbrey AL. Single-Cell RNA Sequencing Reveals Unique Monocyte-derived Interstitial Macrophage Subsets during Lipopolysaccharide-Induced Acute Lung Inflammation. Am J Physiol Lung Cell Mol Physiol. 2023 Apr 1;324(4):L536-549. PubMed PMID: 36852927

View All Publications


Lab Personnel

Alexandra McCubbrey, PhD
Assistant Professor

Stephanie Bersie, MS
Graduate Student

Hope Chatwin
Lab Researcher

Shannon Hott
Senior Lab Researcher

Brian Tooker, MS, PhD
Postdoctoral Fellow

View Collaborators

Contact Us

The McCubbrey Lab is located on the main National Jewish Health campus.

Interested labs should contact Alexandra McCubbrey to discuss opportunities for research collaboration.


Job Opportunities

Postdoctoral researchers seeking to study phagocyte responses to apoptotic cells should contact Alexandra McCubbrey to discuss position availability.