Summary The specificity of T-cell receptor to an antigen is determined by the five variable elements of the a and ß chains. Research scientists at National Jewish Health have developed a method to produce monoclonal antibodies against any of the five variable elements of human T-cell receptor. This method relies on the transfection of human/mouse hybrid T-cell receptor a or ß chains genes into a mouse T-cell hybridoma lacking an endogenous a or b chain gene.
Monoclonal antibodies for therapeutic use.
Advantages of Invention
Method adaptable to any of the five variable elements of the human T-cell receptor.
State of Development Scientists have demonstrated that using this method:
hVß elements can be expressed on the surface of mouse T-cell hybridomas.
The transfected T-cell hybrids are excellent immunogens in mice for hVß.
Monoclonal antibodies against hVß13.1 and -13.2 can be raised and be used for the measurements of Vß13.1 and -13.2 in humans.
Licensing Potential Available for licensing on a non-exclusive basis.
Choi et al. Proc Natl Acad Sci U S A. 1991 Oct 1; 88(19):8357-61. PMID: 1656442
For Further Information, Contact: Emmanuel Hilaire, PhD Director Technology Transfer Office National Jewish Health 1400 Jackson Street, Room M206b Denver, CO 80206 Voice: (303) 398-1262 Fax: (303) 270-2352 HilaireE@njhealth.org