NOTE: THIS TECHNOLOGY IS EXPERIMENTAL AND THEREFORE IT IS NOT AVAILABLE TO HUMANS. IT HAS ONLY BEEN TESTED IN MICE AND DOGS DIAGNOSED WITH AIHA
Summary This invention is using liposomal clodronate as a therapy for autoimmune hemolytic anemia (AIHA).
Therapy for autoimmune hemolytic anemia
The therapy is applicable to both humans and companion animals
Advantages of Invention
The method is less invasive than surgery (splenectomy)
Decrease use of steroids
Decrease side effects
State of Development
The efficacy of this therapy has been demonstrated by some strong in vivo data obtained in mice and dogs with AIHA.
Using a mouse model in which animals were given anti red blood cell antibodies, treatment with liposomal clodronate substantially decreased red blood cell destruction.
In addition, this effect was detected within hours and lasted at least a week.
Further R&D Required Additional in vivo studies with other animal models.
RBC clearance and the effects of LC treatment in dogs with AIHA. RBC clearance in 6 dogs with spontaneous AIHA was assessed by flow cytometry prior to treatment and again 24 hours after treatment with LC and the mean (± SE) percentage of labeled RBC present in circulation at each time point post infusion was determined. (B) RBC clearance kinetics were determined again 24 hours after treatment with 0.5 mL/kg LC. In 4 dogs (Nonresponders), there was no change in RBC clearance compared to clearance prior to treatment with LC, whereas in 2 dogs (Responders), RBC clearance was markedly reduced.
Jordan, M. B., John Kappler, and Pippa Marrack. "Liposomal Clodronate as a Novel Agent for Treating Autoimmune Hemolytic Anemia in a Mouse Model." Blood 101.2 (2002): 594-601. Print. PMID: 12393630.
Mathes, Mark, Michael Jordan, and Steven Dow. "Evaluation of Liposomal Clodronate in Experimental Spontaneous Autoimmune Hemolytic Anemia in Dogs." Experimental Hematology 34.10 (2006): 1393-402. Print. PMID: 16982332.
For Further Information, Contact: Emmanuel Hilaire, PhD Director Technology Transfer Office National Jewish Health 1400 Jackson Street, Room M206b Denver, CO 80206 Voice: 303.398.1262 Fax: 303.270.2352 HilaireE@njhealth.org