Michael E. Wechsler, MD, MMSc

Michael E. Wechsler
Co-Director, The Cohen Family Asthma Institute
Professor
Department of Medicine
Division of Pulmonary, Critical Care & Sleep Medicine
America’s Top Doctors 2018 — Castle Connolly Medical, Ltd.
Michael E. Wechsler, MD, is a pulmonologist at National Jewish Health. Dr. Wechsler is in the Division of Pulmonary, Critical Care and Sleep Medicine.

Special Interests

My primary research focuses on clinical and translational asthma research, with three main foci of investigation: (i) asthma genetics and personalized medicine; (ii) clinical trials in asthma; and (iii) Churg-Strauss Syndrome. Regarding the genetics of asthma, I have investigated the role of numerous candidate gene polymorphisms in the pathogenesis and management of asthma. I was the Principal Investigator of the Lancet-published, NHLBI-funded Asthma Clinical Research Network’s LARGE trial, which prospectively investigated the effect of beta-adrenergic receptor polymorphisms on the asthmatic response to salmeterol. I also led a recently completed Partners Genetics Enters Medicine Initiative funded trial examining genotype-stratified treatment with anticholinergics vs. beta-agonists (long acting) and exacerbations (GABLE) in asthma (currently undergoing analysis).

I was a site Principal Investigator examining the effects of a novel therapy for asthma (bronchial thermoplasty) that utilizes thermal energy to disrupt airway smooth muscle and presented study data to the FDA Medical Advisory panel in 2009, leading to its 2010 FDA approval. I was also awarded an NIH sponsored R21 award to examine the effects of placebo on lung function in asthma, and completed this clinical trial work in over 40 subjects. Having reported on the importance of using placebos in clinical trials and on the relevance of patient reported outcomes in clinical trials, my NEJM manuscript has reset the standard for clinical trial design in this condition. I am a member of the Steering Committee of the NIH-sponsored Asthma Clinical Research Network (ACRN, now called Asthmanet), a multi-center asthma clinical trials consortium that has conducted numerous trials that have clarified our understanding of asthma phenotyping and asthma management, laying the foundation for current asthma guidelines. As a member of this consortium, I was the lead investigator who described an association between asthma treatment failures and beta agonist use in African Americans , and am a lead investigator in 2 seprate trials examining race-specific differences in response to asthma therapy.

A major focus of my research efforts is elucidating the pathophysiology of the Churg-Strauss syndrome, a rare form of eosinophilic vasculitis. I was the first to describe the relationship between CSS and leukotriene modifiers, and between CSS and anti-IgE therapy for asthma . I clinically follow one of the largest cohorts of CSS patients in the country and I serve as a referral base for patients with severe asthma from all over the USA. This expertise, and two research awards, have enabled me to recruit the largest cohort of CSS patients, which are serving as the primary test population in a genome-wide association study of CSS. I have examined the role of anti-IL5 in the treatment of CSS patients and have received NIAID R34 funding to plan a double blind placebo controlled trial in this patient population, that is set to start in 2013.

Education

Education
Harvard Medical School, Boston, MA, MMSc, Master in Medical Science
McGill University School of Medicine, Montreal, Quebec, MD, Medicine
Harvard University, Cambridge, MA, AB magna cum laude, Biochemical Science
Residency
West Roxbury VA Medical Center, W. Roxbury, MA, Chief Medical Resident, Internal Medicine
Beth Israel Hospital, Boston, MA, Intern/Resident, Internal Medicine
Fellowship
Brigham and Women’s Hospital, Boston, MA, Harvard Pulmonary and Critical Care Medicine Fellowship, Research Fellow
Beth Israel Medical Center, Brigham and Women’s Hospital Massachusetts General Hospital, Boston, MA, Harvard Pulmonary and Critical Care Medicine Fellowship, Clinical Fellow

Awards & Recognition

Present: Associate Editor, Allergy
2003: Research Award, Clinical, Merck
2002: Research Award, American Lung Association
2001: Young Investigator Special Project Award, Respiratory, Merck
1999: Young Investigators Meeting (participant), Respiratory, Merck
1998: Investigator Award, Clinical Research, American College of Chest Physicians, CHEST Foundation
1993: Campbell Howard Prize, Clinical Medicine, McGill University
1993: Dr. A Macdonald Award, Medicine, McGill University
1990: James Q Bliss Prize, Medical Physiology, McGill University
1986-1989: Dean’s List, Harvard College
1986-1989: Harvard College Scholarship, Harvard College
 
Ad hoc reviewer:
New England Journal of Medicine
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory Cellular Molecular Biology
American Journal of Medicine
Journal of Allergy and Clinical Immunology
Chest
Thorax
Drug Safety
The Pharmacogenomics Journal
Nature Clinical Practice
JAMA
Respiratory Care Journal
Cleveland Clinic Journal of Medicine
European Respiratory Journal
Revista Portuguesa de Pneumologia, Portuguese Journal of Pulmonology
The Medical Letter
Mount Sinai Journal of Medicine
The Lancet
Arthritis and Rheumatism

Board Certification

1999 (Recertified 2009): Diplomate, Subspecialty of Critical Care Medicine, American Board of Internal Medicine
1998 (Recertified 2009): Diplomate, Subspecialty of Pulmonary Disease, American Board of Internal Medicine
1996: Diplomate, American Board of Internal Medicine

Professional Memberships

2012-present: Member, American Society for Clinical Investigation
2012-present: Member, International Eosinophil Society
1993-present: Member, Massachusetts Medical Society
2002-2005: Member, American Academy of Asthma, Allergy and Immunology
1996-2000: Member, American College of Chest Physicians
1993-1999: Member, American Medical Association

Publications

Wechsler ME, Shah P, Niven R, Thomson N, Rubin A, Fiterman J, Lapa JR, Laviolette M, Olivenstein R, Hales JB, Shifren A, Cox G, Shargill NS, Armstrong B, Castro M for the AIR2 Trial Study Group. Benefits of Bronchial Thermoplasty Persist Out to 5 Years in Patients with Severe Asthma. ATS 2013

Wechsler ME, Kelley JM, Boyd IOE, Dutile S, Marigowda G, Kirsch I, Israel E Kaptchuk TJ. Active or Placebo Albuterol, Sham Acupuncture or No Treatment in Asthma. New Engl J Med 2011 365(2):119-126.(PMID: 21751905)
 

Wechsler ME, Castro M, Lehman E, Chinchilli V, Rand Sutherland E, Denlinger L, Lazarus SC, Peters SP, Israel E, the NHLBI Asthma Clinical Research Network.  Impact of race on asthma treatment failures in the Asthma Clinical Research Network. Am J Respir Crit Care Med 2011 184:1247-1253.  (PMID: 21885625)

Castro M, Rubin A, Laviolette M, Hanania NA, Armstrong B, Cox G; AIR2 Trial Study Group*.  Persistence of effectiveness of bronchial thermoplasty in patients with severe asthma.  Ann Allergy Asthma Immunol. 2011 Jul;107(1):65-70. Epub 2011 Apr 14 (PMID: 21496892)

Castro M, Rubin AS, Laviolette M, Fiterman J, Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, ten Hacken NHT, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Berry SM, Quiring J, Shargill NS, Cox G. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma:  A multicenter, randomized, double-blinded, sham-controlled clinical trial.  Am. J. Respir. Crit. Care Med. 2010;181(2):116-24 (PMCID: PMC2914569)


Castro M, Wechsler ME, Cox G. Bronchial thermoplasty is safe and effective for patients with severe asthma.  Am. J. Respir. Crit. Care Med. 2010;182(12): p. 1565-1567

Hales J, Wechsler ME, Niven N, Prys-Picard C, Castro M, Cox G. Patient Selection for Bronchial Thermoplasty (BT) Following FDA Approval: Lessons Learned from Multiple Clinical Trials. ACAAI 2010
 

Kim S, Oren E, Marigowda G, Israel E, Wechsler ME. Mepolizumab as a steroid sparing agent in Churg-Strauss syndrome. J Allergy Clin Immunol 2010; 125(6):1336-43 (PMCID: PMC2964431).

Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske Jr RF, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman S, Israel E.  Effect of beta2-adrenergic receptor polymorphism on response to long acting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomized, placebo-controlled, crossover trial.  The Lancet.  2009; 374(9703):1754-64. (PMCID: PMC2914569)

Wechsler M, Olivenstein R, Niven R, Pavord I, for the AIR2 Study Group. Reduction in Asthma-Related ER Visits and Hospitalizations Following Bronchial Thermoplasty (BT) in Patients with Severe, Symptomatic Asthma. Am J Respir Crit Care Med /ATS 2009

Wechsler ME. Bronchial thermoplasty for asthma: a critical review of a new therapy. Allergy Asthma Proc. 2008; 29(4):365-70

Hospital Affiliations

  • Colorado Acute Long Term Hospital
  • Rose Medical Center
  • St. Joseph Hospital - Denver
  • Swedish Medical Center

Website Information

Asthma Program

Conflicts of Interest

National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.

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Contact Information

  • Office: 877.225.5654
  • Fax: 303.398.1780
  • Email: WechslerM@njhealth.org

 

Locations

  • National Jewish Health Main Campus
    1400 Jackson St.
    Denver, CO 80206

  • Saint Joseph Hospital
    1835 Franklin Street Denver, CO 80218

Patient Ratings

The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey. This survey is about the patient care experience and does not address crucial characteristics like medical decision-making, prescribing the best therapy, and patient outcomes.

Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey.
 

Provider showed concern
4.9

Friendliness
4.9

Spoke using clear language
5

Provider explained things clearly
4.9

Amount of time spent with you
5

Provider included you in decisions
5

Confidence in your doctor
5

Likelihood of recommending this provider
4.9
 

Comments

Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.
 

National Jewish Health PatientJune, 2018
I have never been to a doctor who took as much time as Dr. Wechsler did. He did not rely on what he already knew about my condition which had been ongoing for over a year, but instead, wanted me to give a detailed description of what had happened. He was also interested in me as a person. My daughter was with me, and he answered all of her questions as well. I am very grateful to have found Dr. Wechsler.

National Jewish Health PatientMay, 2018
Caring, thoughtful, informative.

National Jewish Health PatientMarch, 2018
I would like more information regarding the diagnosis and prognosis of the disease.

National Jewish Health PatientMarch, 2018
*Dr. Wechsler is by far the best [CONDITION] doctor I have ever had.

National Jewish Health PatientMarch, 2018
He is the example of the physician you would tell everyone to see. His attention to my concerns and obvious concern for my health and understanding was outstanding

National Jewish Health PatientMarch, 2018
I know he is moving out of practicing and doing more studies.

National Jewish Health PatientJanuary, 2018
*Dr. Wechsler is the best most caring knowledgeable physician I have ever had.

National Jewish Health PatientDecember, 2017
*Dr. Wechsler to me by [PROVIDER] when he retired. It doesn't get any better for both drs.

National Jewish Health PatientOctober, 2017
Dr. Wechsler is in an elite category of doctors on this planet of which only 2 I have met in my [AGE] years of life. He is a compassionate listener, a quality human being and I feel both honored and humbled to have him as my doctor. In the years I have seen Dr. Wechsler he has never dropped the ball or dismissed my feelings, questions or concerns. He is available and responds almost as fast as the speed of light. As an artist my best comparison for Dr. Wechsler would be similar to Leonardo in talent and intelligence.

National Jewish Health PatientAugust, 2017
I have been very favorably impressed with Dr. Wechsler;s willingness to answer all my questions and to discuss them in detail.

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