James D. Crapo, MD Ask a Question Refer Patient James D. Crapo, MD, is a pulmonologist at National Jewish Health. Dr. Crapo is in the Division of Pulmonary, Critical Care and Sleep Medicine. Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine 5280 Top Doctors 2021 Previously a 5280 Top Doctor America’s Top Doctors 2015 — Castle Connolly, Medical, Ltd. Recognized in America’s Top Doctors — Castle Connolly, Inc. Best Doctors in America® 2019-2020 — Best Doctors, Inc. Recognized in Best Doctors in America® — Best Doctors, Inc. America’s Top Doctors 2020 — Castle Connolly Medical, Ltd. Email Profile Print Profile Overview Contact Info & Locations Patient Ratings & Comments Programs & Services COPD Program Department of Medicine Division of Pulmonary, Critical Care and Sleep Medicine (Adult) Specialties & Conditions Chronic Cough Chronic Obstructive Pulmonary Disease (COPD) Emphysema Research Areas Chronic Obstructive Pulmonary Disease (COPD) Special Interests Research Interests From 1972 to the present research efforts have focused on mechanisms of oxidative injury and the role of antioxidants in blocking both normal and abnormal oxidative stress. A major emphasis has been on the role of extracellular superoxide dismutase as a regulator of inflammation and of intercellular signal transduction. This laboratory is developing small molecular weight catalytic antioxidants that can be used as drugs and as molecular probes to determine the role of free radicals in normal biology and in disease processes such as radiation-induced injury, stroke, diabetes, chronic lung disease and cancer. In 2007, the COPDGene project was launched with Dr. Crapo and Dr. Ed Silverman as principal investigators. COPDGene is an NHLBI funded multi-institutional genetic epidemiology study which will carry out a genome-wide analysis of 10,500 subjects at risk for or with COPD to identify the primary genes that determine risk for developing COPD. News & Videos Millions of Smokers May Have Undiagnosed Lung Disease National Jewish Health Faculty Earn Three Awards From the American Thoracic Society New Diagnostic Criteria Proposed For Chronic Obstructive Pulmonary Disease (COPD) Education Education 1971 University of Rochester (New York), MD 1967 Brigham Young University, BS Residency 1975 - 1976 Duke University, 1971 - 1972 Harbor General Hospital, Torrance, CA, Internship Fellowship 1975 - 1977 Duke University, Pulmonary Medicine 1972 - 1975 National Institute of Environmental Health Sciences, Research Triangle Park, NC, Staff Associate Awards & Recognition 2003-Present: Editor, Journal of Chronic Obstructive Pulmonary Disease 1999: Presidential Citation, American Thoracic Society Board Certification American Board of Internal Medicine American Board of Pulmonary Diseases Professional Memberships American Thoracic Society American Physiological Society American Society for Clinical Investigation American College of Physicians Fleischner Society Association of American Physicians American College of Chest Physicians The Oxygen Society Publications Regan EA, RP Bowler and JD Crapo. Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscropically intact cartilage and subacute injury. Osteoarthritis Cartilage 16:515-521, 2008. Petersen SV, T Kristensen, JS Petersen, L Ramsgaard, TD Oury, JD Crapo, NC Nielsen and JJ Enghild. The folding of human active and inactive extracelluar superoxide dismutases is an extracellular event. J Biol Chem 283:15031-15036, 2008. Gridley DS, AY Makinde, X Luo, A Rizvi, JD Crapo, MW Dewhirst, BJ Moeller, RD Pearlstein and JM Slater. Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model. Anticancer Research 27:3101-3110, 2007. Kinnula VL and JD Crapo. Superoxide dismutases in malignant cells and human tumors. Free Radic Biol Med 36:718-744, 2004. Kinnula VL and JD Crapo. Superoxide dismutases in the lung and human diseases. Am J Respir Crit Care Med 167:1600-1619, 2003. Academic Affiliations Professor of Medicine, University of Colorado Denver Teaching & Professional Positions 1996- present: Professor of Medicine, National Jewish Health, and University of Colorado Denver 1996- 2008: Director, Clinical Science Graduate Program, University of Colorado Denver 1996-2004: Associate Dean, School of Medicine, University of Colorado Denver 1996-2004: Executive Vice President of Academic Affairs, National Jewish Health 1996-2004: Chair, Department of Medicine, National Jewish Health 1979-1996: Chief, Division of Allergy, Critical Care and Respiratory Medicine, Duke University, Durham, NC Conflicts of Interest National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations. Ask a Question through Patient Portal Sign in to your My National Jewish Health patient portal account to communicate with your care team, manage appointments, and more. Create an Account Contact Information Office: 877.225.5654Fax: 303.270.2249 Locations National Jewish Health Main Campus 1400 Jackson St. Denver, CO 80206 Patient Ratings The Patient Rating score is an average of all responses to care provider related questions on our independent rating system, the Press Ganey Patient Satisfaction Survey. This survey is about the patient care experience and does not address crucial characteristics like medical decision-making, prescribing the best therapy, and patient outcomes. Responses are measured on a scale of 1 to 5, with 5 being the best score. Learn more about our patient satisfaction survey. Comments Comments are collected in our Press Ganey Patient Satisfaction Surveys. Patients are de-identified to protect confidentiality and patient privacy. Learn more about our patient satisfaction survey.