My clinical interests are in critical care medicine and chronic obstructive pulmonary disease. I also specialize in the treatment of septic shock, acute lung injury, and ARDS (acute respiratory distress syndrome).
My research is focused on mechanisms of repair following acute and chronic lung injury. This includes studying how lung collectins influence alveolar macrophage phenotype, function, and fate in healthy lungs and during inflammation. I am also interested in the role that bone-marrow-derived stem cells (including endothelial progenitor cells) play in recovery from lung injury.
Sareli AE, Janssen WJ, Sterman D, Saint S, Pyeritz RF. What’s the connection? New Eng J. Med. 2008; 358(6):626-32.
Ezzie E, Janssen WJ, O’Brien, JM, Fox C, Schwarz MI. Failure to respond, New Eng J Med. 2008; 358(1):70-4.
Linderman DL, Janssen WJ. Critical care medicine for the hospitalist. Med Clin N. America 2008;92:467–479.
Janssen WJ, McPhillips KA, Dickinson MG, Derek J. Linderman DJ, Morimoto K, Xiao YQ, Oldham KM, Vandivier RW,Henson PM, Gardai SJ.Surfactant Proteins A and D Tonically Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRP?. Am J Respir Cell Crit Care Med. 2008;178)2):158-67
McPhillips K, Janssen WJ, Ghosh M, Byrne A, Gardai SJ, Remigio L, Bratton DL, Kang JL, Henson PM. TNFa inhibits macrophage clearance of apoptotic cells via cPLA2 and oxidant-dependent mechanisms. J Immunol. 2007;178(12):8117-2612.