David E. Griffith, MD

Special Interests

My major areas of interest spanning more than 30 years are mycobacterial diseases, including both nontuberculous mycobacterial (NTM) disease and tuberculosis, and bronchiectasis. I started my career in NTM lung disease with the invaluable encouragement of Dr. Richard Wallace more than 30 years ago. In the mid 1980’s there were very few centers interested in NTM lung disease in the United States or anywhere else in the world. Over the last 3 decades I have participated in multiple clinical trials and research projects that have resulted in the establishment of standards for treatment of patients with NTM diseases. I have been fortunate to work in the top two-referral centers for NTM disease in the United States where consultations are provided regionally and nationally to clinicians and patients. I have participated in the development of 3 iterations of nontuberculous mycobacterial disease diagnosis and treatment guidelines (1997, 2007, 2020) including as the principal author for the 2007 American Thoracic Society and Infectious Diseases Society of America Guidelines for the Diagnosis, Treatment and Prevention of Nontuberculous Mycobacterial Diseases. I am author or co-author on approximately 250 peer reviewed publications mostly pertaining to NTM disease including original research manuscripts, book chapters, reviews, editorials and electronic publications.

Awards & Recognition

2002-2019: W.A. and E.B. Moncrief Distinguished Professorship in Comprehensive Heart and Lung Research
2012: Murray Kornfeld Memorial Founders Lecture and Award, American College of Chest Physicians
2010-Present: Royal Society of Medicine, Overseas Fellow

Board Certification

1980: Internal Medicine
1986: Pulmonary Medicine

Professional Memberships

Fellow American College of Physicians
Fellow American College of Chest Physicians
Overseas Fellow, Royal Society of Medicine
American Thoracic Society

Publications

Griffith DE, Eagle G, Thomson R, Aksamit TR, Hasegawa N, Morimoto K, Addrizzo-Harris DJ, O'Donnell AE, Marras TK, Flume PA, Loebinger MR, Morgan L, Codecasa LR, Hill AT, Ruoss SJ, Yim JJ, Ringshausen FC, Field SK, Philley JV, Wallace RJ Jr, van Ingen J, Coulter C, Nezamis J, Winthrop KL; CONVERT Study Group. Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT): A Prospective, Open-Label, Randomized Study. Am J Respir Crit Care Med. 2018 Sep 14

Griffith DE, Flume PA, Thomson R, Mange K, Yuen DW, Morimoto K, Ruoss SJ, Codecasa LR, Yim Jae-Joon, Marras TK, van Ingen J, Wallace RJ, Brown Elliott BA, Coulter C, Winthrop KL.A Randomized, Open-Label, Multicenter Study of Liposomal Amikacin for Inhalation (LAI) in Adult Subjects with Nontuberculous Mycobacterial (NTM) Lung Infections Caused by Mycobacterium avium Complex (MAC) That Are Refractory to Treatment (submitted)

104. Charles L. Daley, Jonathan M. Iaccarino, Christoph Lange, Emmanuelle Cambau, Richard J. Wallace Jr, Claire Andrejak, Erik C. Böttger, Jan Brozek, David E. Griffith, Lorenzo Guglielmetti, Gwen A. Huitt, Shandra L. Knight, Philip Leitman, Theodore K. Marras, Kenneth N. Olivier, Miguel Santin, Jason E. Stout, Enrico Tortoli, Jakko van Ingen, Dirk Wagner, Kevin L. Winthrop. Treatment of Nontuberculous Mycobacterial Pulmonary Disease: An Official ATS/ERS/ESCMID/IDSA Clinical Practice Guideline (In press, Clinical Infect Dis) 

Winthrop KL, Flume PA, Thomson R, Mange K, Yuen DW, Morimoto K, Ruoss SJ, Codecasa LR, Yim Jae-Joon, Marras TK, van Ingen J, Wallace RJ, Brown Elliott BA, Coulter C, Griffith DE. Safety and Tolerability of Amikacin Liposome Inhalation Suspension in Treatment-Refractory Mycobacterium avium complex Lung Disease: A 12-Month Open-Label Extension Study (submitted)

55. Griffith DE, Aksamit T, Brown-Elliott B, Catanzaro, Daley C, A Gordin F, Holland S, Horsburgh, Huitt G, Iademarco M, Iseman M, Olivier K, Ruoss S, von Reyn CF, Wallace RJ, Jr. An Official ATS/IDSA Statement: Diagnosis, Treatment and Prevention of Nontuberculous Mycobacterial Diseases. Am J Respir Crit Care Med. 2007; 175: 367-416.

Teaching & Professional Positions

Professor of Medicine, University of TX Health Science Center, Tyler, TX
Professor of Medicine, National Jewish Health