Elizabeth F. Redente
Assistant Professor
Department of Pediatrics
Division of Cell Biology
image descriptionPrograms & Services
Specialties and ConditionsSpecialties & Conditions
Research AreasResearch Areas
  • Fibroblast biology
  • Interstitial Lung Disease (ILD)
  • Macrophage biology
  • Pulmonary Fibrosis

Special Interests

My career interests are focused on the interactions between TNF-α, macrophages and myofibroblasts and their role in the resolution of established pulmonary fibrosis with the goal to investigate the mechanisms by which TNF-α resolves fibrosis as the basis for the translational application of this work as a potential therapeutic. We plan to elucidate the mechanisms by which TNF-α is reducing the pro-fibrotic phenotype of macrophages and myofibroblasts and via the creation of an anti-fibrotic lung microenvironment.  The importance of understanding how macrophages are shaping the lung environment during disease and how these interactions can be modulated to influence disease resolution is an important research direction that can be applied to many diseases including fibrosis and cancer. It is my goal that my basic science findings conducted in mouse models be translatable to human disease and into potential therapeutic treatments.

Education

Education
University of Colorado Denver, PhD

Publications

Redente EF, Jacobsen KM, Solomon J, Lara A, Faubel S, Keith RC, Henson P, Downey GP, Riches DWH.  2011.  Age and gender dimorphisms contribute to the severity of bleomycin-induced lung injury and fibrosis.  Am J Physiol (LCMP) 301(4):L510-8.

Keith RC, Powers JL, Redente EF, Sergew A, Martin RJ, Gizinski A, Holers M, Sakaguchi S, Riches DWH.  2012. A novel model of rheumatoid arthritis-associated interstitial lung disease in SKG mice.  Exp Lung Res. 38(2):55-66.

Keith RC, Sokolove J, Edelman BL, Lahey L, Redente EF, Holes M, Sakaguchi S, Robinson WH, Riches DWH. 2013. Androgens are protective in the sexually dimorphic development of arthritis and lung disease in SKG mice. Arthritis & Rheum. Jun;65(6):1487-93.

Redente EF, Keith RC, Janssen W, Ortiz LA, Downey GP, Bratton DL, Riches DWH. 2013. TNF-α accelerates the resolution of pulmonary fibrosis in mice by reprogramming lung macrophages. Am J of Respir Cell and Mol Biol. 50(4):825-837. PMID: 24325577

Riches DWH, Backos DS, Redente EF. 2015. “ROCK and Rho” – Critical therapeutic targets to ameliorate pulmonary fibrosis. Am J Path. Apr;185(4):909-12. PMID: 25687558

Academic Affiliations

Assistant Professor of the University of Colorado School of Medicine, Department of Medicine, Division of Pulmonary Sciences and Criticial Care Medicine

Teaching & Professional Positions

Research Scientist, Veterans Affairs Eastern Colorado Health Care System 

Contact Information

  • Office: 303.398.1548
  • Email: RedenteE@njhealth.org

 

Locations

  • National Jewish Health Main Campus
    1400 Jackson St.
    Denver, CO 80206

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