Gregory P. Downey, MD

Awards & Recognition

2010: American Thoracic Society Recognition Award for Scientific Accomplishments

2002-Present: Assoc. Editor, American Journal of Respiratory Cell and Molecular Biology

2006: Canadian Cystic Fibrosis Foundation Zeller’s Senior Scientist Award for outstanding contributions to CF Research

2004: Scholar, McLaughlin Centre for Molecular Medicine, U. of Toronto

2001: Tier 1 Canada Research Chair in Respiration, Canadian Institutes of Health Research

1999: R. Fraser Elliott Chair in Transplantation Research, Toronto General Hospital, University Health Network

1999: Dept. of Med. Research Award, U. of Toronto

1997: Elected to the American Society for Clinical Investigation. Recipient of the William Goldie Prize, Dept. of Med., U. of Toronto for a contribution of notable merit to the advancement of knowledge in Internal Medicine

1996: Institute of Medical Science, Dept. of Medicine, U. of Toronto. Special Recognition for Supervision of Graduate Students who have made a notable scientific contribution

1992: Royal College of Physicians and Surgeons of Canada, Canadian Society of Clinical Investigation Joe Doupe Young Investigator’s Award

1989: Career Scientist Award, Ontario Ministry of Health

Board Certification

National Board of Medical Examiners, Parts 1, 2 and 3

American Board of Internal Medicine

Fellow of the Royal College of Physicians and Surgeons of Canada Royal College of Physicians and Surgeons of Canada: Special Certificate in Respiratory Diseases

American Board of Pulmonary Diseases

Special Certification in Critical Care (American Board of Internal Medicine)

Fellow of the American College of Chest Physicians

Professional Memberships

Royal College of Physicians and Surgeons of Canada, Full Member

American Thoracic Society, Full Member; Member Program Committee for Assembly on Allergy, Immunology, and Inflammation, 1996-Present

American College of Chest Physicians, Full Member

Member of Forum on Critical Care

American Society for Cell Biology, Full Member.

Scientific Forum on Lung Cell and Molecular Biology

American Association for the Advancement of Science, Full Member

Ontario Thoracic Society, Full Member

Federation of American Societies for Experimental Biology, Full Member

Clinical Research Society or Toronto, President, 1996-1999

Publications

McCormack FX, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF,  Chapman JT,  Brantly ML, Stocks JM,  Brown KK,  Lynch JP, 3rd, Goldberg HL, Young LR, Kinder BM,  Downey GP, Sullivan ET, Colby TV, McKay RT,  Cohen MM,  Korbee L, Taveira-DaSilva AM, Lee H-S, Krischer JP, and Trapnell BC, for the NIH Rare Lung Diseases Consortium and the Multicenter International Lymphangioleiomyomatosis Efficacy and Safety of Sirolimus (MILES) Trial. Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis. N Eng J Med. 364;1595-1606, 2011. PMC3118601

Yamashita C, Dolgonos L, Zemans RL, Young SK, Robertson J, Briones N, Suzuki T, Campbell MN, Gauldie J, Radisky DC, Riches DW, Yu G, Kaminski N, McCulloch CA, and GP Downey.  Matrix metalloproteinase-3 is a mediator of pulmonary fibrosis.  Am J Path 179:1733-45, 2011. PMC3181358.

Zemans R, Briones N, Campbell M, McClendon J, Young SK, Suzuki T, Yang IV, de Langhe S, Reynolds SD, Mason RJ, Kahn M, Henson PM, Colgan SP, and GP Downey. Neutrophil transmigration triggers repair of the lung epithelium via β-catenin signaling.  Proc Nat Acad Sci (USA) 108:15990-15995, 2011. PMC3179042.

Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, and DP Radisky.  Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Sci Transl Med 4(142):142ra95, 2012. PMC3733503.

Zemans R, McClendon J, Aschner Y, Briones N, Young SK,. Lau LF, Kahn M, and GP Downey. Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. Am J Physiol (Lung Cell Mol Physiol) 304: L415-27, 2013. PMC3602744.

Hospital Affiliations

• Hospital for Sick Children
• Mt. Sinai Hospital
• Toronto General Hospital

Teaching & Professional Positions

2007-Present: Professor, Dept of Pediatrics, National Jewish Health

2007-Present: Professor, Integrated Department of Immunology, National Jewish Health & University of Colorado Denver

2006-Present: Executive Vice President for Academic Affairs and Professor, Dept of Medicine, National Jewish Health

2004-2006: Vice-Chair, Dept of Medicine, University of Toronto

2001-2006: Canada Research Chair in Respiration, Canadian Institutes of Health Research

2001-2006: Associate Director, Institute of Medical Sciences, University of Toronto 8/01-10/30/06

2000-2006: Director, Division of Respirology, University of Toronto

1999-2006: Professor, Dept of Medicine, University of Toronto

1999-2005: R. Fraser Elliot Chair in Transplantation Research, Toronto General Hospital, The University Health Network

1995-2000: Training Program Director, Division of Respirology, University of Toronto

1993-2006: Full Member, School of Graduate Studies, University of Toronto

1993-1999: Associate Professor, Dept of Medicine, University of Toronto

1989-1993: Associate Member, School of Graduate Studies, University of Toronto

1988-1993: Assistant Professor, Dept of Medicine, University of Toronto

1987-1988: Assistant Professor, Dept of Medicine, University of Colorado Denver

Conflicts of Interest

National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.