Understanding Sarcoidosis Make an Appointment Ask a Question Search Conditions This information has been reviewed and approved by Lisa Maier, MD, MSPH, FCCP (July 2022). Understanding Sarcoidosis Sarcoidosis causes the immune system to overreact and produce clusters of inflammation, called granulomas, usually in the lungs. Cause Sarcoidosis has more than one cause, but the exact cause is still unknown. More Commonly In People of African or Northern European descent Women Ages 30 to 50 Signs and Symptoms Weight loss Night sweats Low-grade fever Fatigue Shortness of breath, cough Enlarged or painful chest lymph nodes Lightheadedness and heart issues Red, painful, dry eyes; vision issues Raised, pink or purple; painful nodules under the skin Enlarged spleen or liver Some of people with sarcoidosis have no symptoms. Diagnosis Medical exam Chest X-ray or CT scan Biopsy showing granulomas Treatment Medications Oxygen therapy Pulmonary rehabilitation More Information on Sarcoidosis Understanding sarcoidosis Sarcoidosis Sarcoidosis Symptoms Sarcoidosis Diagnosis Sarcoidosis Treatment Living with Sarcoidosis Want to use this on your website? Fill out the content usage request form and then copy this code: