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Immune Deficiency and Immune Dysregulation Disorders

Immune deficiency and dysregulation disorders are more common than most realize. According to the Immune Deficiency Foundation, there are more than 400 primary immune deficiencies. Add to that acquired immune disorders, and the number grows climb steadily. Unfortunately, many who have these diseases are undiagnosed or misdiagnosed.

At National Jewish Health in Denver, we have one of one of the most advanced immune deficiency and dysregulation disorders programs in Colorado. Our specialists have a deep level of expertise diagnosing and treating the most complex primary and acquired immune disorders. And, as part of the nation’s leading respiratory hospital, our team has extensive experience treating immune disorders that impact the lungs.

Our program offers coordinated care from experts in multiple specialties, state-of-the-art diagnostic and genetic testing, personalized treatments and access to the latest clinical trials and therapies. Our goal is to make sure our patients receive the right diagnosis and care to improve their quality of life.


Immune Disorders We Treat

Activated PI3K delta syndrome
Chronic mucocutaneous candidiasis
Chronic granulomatous disease
Combined Immune Deficiency Diseases
Common Variable Immune Deficiency
Complement deficiency
Complications associated with immune dysregulation
DiGeorge Syndrome and other congenital athymic diseases
Disorders of cytokine signaling
Hemophagocytic lymphohystiocytosis (HLH)
Mendelian susceptibility to mycobacterial diseases
Periodic fever syndromes/Autoinflammatory diseases
Specific antibody deficiency
Wiskott Aldrich syndrome
X-linked (Bruton’s) agammaglobulinemia


  • Rafeul Alam

    Rafeul Alam, MD, PhD

  • Jordan Bull

    Jordan Bull, PA-C

  • Jessica Galant-Swafford

    Jessica Galant-Swafford, MD

  • Flavia Cecilia Lega Hoyte

    Flavia Cecilia Lega Hoyte, MD

  • Rohit K. Katial

    Rohit K. Katial, MD

  • Kanao Otsu

    Kanao Otsu, MD, MPH

  • Eileen Wang

    Eileen Wang, MD, MPH

Reasons to Choose National Jewish Health

  • The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses
  • Ranked #1 or #2 in Pulmonology by U.S. News & World Report for 26 consecutive years
  • Ranked in the top 5% of hospitals in the nation by HCAHPS
  • Physicians consistently recognized among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly
  • Among the top 6% of organizations funded for research by the NIH, providing patients access to hundreds of active clinical trials
  • 124-year history of focus on care, research and education serving patients from around the world with lung, heart, immune and related disorders
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