Alpha-1 Antitrypsin Deficiency Make an Appointment Refer a Patient Ask a Question Make an Appointment Refer a Patient Ask a Question Alpha-1 Antitrypsin Deficiency (often called simply “Alpha-1”) is an inherited condition that can cause liver disease in people of all ages and can lead to lung disease in adults. Alpha-1 is one of the most common inherited disorders. It accounts for about one percent of all cases of chronic obstructive pulmonary disease (COPD) in the United States. National Jewish Health in Denver, Colorado, is one of the best places in the world to be treated for the adult lung and liver disease caused by Alpha-1. Our program has been devoted to the care of families with Alpha-1 since 1981, and our doctors have been involved in nearly every new drug evaluated for Alpha-1 treatment. Our doctors are researchers, too, so you have access to the latest Alpha-1 clinical trials and most effective therapies. Alpha-1 Care at National Jewish Health At National Jewish Health, you’ll find: The latest in clinical trials A focused and integrated approach State-of-the-art diagnostic testing The latest and best therapies Rehabilitation services Continued follow-up to meet your changing needs. Learn more about the Alpha-1 Treatment Program. Condition Information Alpha-1 Antitrypsin Deficiency Overview More Less Alpha-1 Lung Disease Alpha-1 Liver Disease Asthma Overview Bronchiectasis Overview COPD Overview Emphysema Lung Cancer: Overview Nontuberculous Mycobacteria (NTM) Overview Search Conditions A-Z Programs & Services Alpha-1 Antitrypsin Deficiency Program More Less COPD Program Department of Medicine Division of Pulmonary, Critical Care and Sleep Medicine (Adult) Infectious Diseases Inpatient and Extended Outpatient Program Search Directory Our Specialists Irina Petrache, MD + × Irina Petrache, MD Chief, Division of Pulmonary, Critical Care & Sleep Medicine Professor of Medicine Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Wollowick Chair in COPD Research Irina Petrache, MD, is a pulmonologist at National Jewish Health. Dr. Petrache serves as Chief of the Division of Pulmonary, Critical Care and Sleep Medicine. View Full Profile Make an Appointment Karina A. Serban, MD + × Karina A. Serban, MD Assistant Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Karina A. Serban, MD, is a pulmonologist at National Jewish Health. Dr. Serban is in the Division of Pulmonary, Critical Care and Sleep Medicine. View Full Profile Patient Rating 4.9 out of 5 stars Make an Appointment Robert A. Sandhaus, MD, PhD, FCCP + × Robert A. Sandhaus, MD, PhD, FCCP Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Robert A. Sandhaus, MD, is a pulmonologist at National Jewish Health. Dr. Sandhaus is in the Division of Pulmonary, Critical Care and Sleep Medicine. View Full Profile Make an Appointment James K. O'Brien, MD, FACP, FCCP + × James K. O'Brien, MD, FACP, FCCP Assistant Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Section of Critical Care Medicine James K. O'Brien, MD, is a pulmonologist at National Jewish Health. Dr. O'Brien is in the Section of Critical Care Medicine and Department of Medicine. View Full Profile Make an Appointment James K. O'Brien, MD, FACP, FCCP + × James K. O'Brien, MD, FACP, FCCP Assistant Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Section of Critical Care Medicine James K. O'Brien, MD, is a pulmonologist at National Jewish Health. Dr. O'Brien is in the Section of Critical Care Medicine and Department of Medicine. View Full Profile Make an Appointment Irina Petrache, MD + × Irina Petrache, MD Chief, Division of Pulmonary, Critical Care & Sleep Medicine Professor of Medicine Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Wollowick Chair in COPD Research Irina Petrache, MD, is a pulmonologist at National Jewish Health. Dr. Petrache serves as Chief of the Division of Pulmonary, Critical Care and Sleep Medicine. View Full Profile Make an Appointment Robert A. Sandhaus, MD, PhD, FCCP + × Robert A. Sandhaus, MD, PhD, FCCP Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Robert A. Sandhaus, MD, is a pulmonologist at National Jewish Health. Dr. Sandhaus is in the Division of Pulmonary, Critical Care and Sleep Medicine. View Full Profile Make an Appointment Karina A. Serban, MD + × Karina A. Serban, MD Assistant Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Karina A. Serban, MD, is a pulmonologist at National Jewish Health. Dr. Serban is in the Division of Pulmonary, Critical Care and Sleep Medicine. View Full Profile Patient Rating 4.9 out of 5 stars Make an Appointment Find a Doctor Appointments & QuestionsPatient Education& SupportVisitingUsTests& ProceduresWays toGiveNational Jewish Health offers every patient access to a team of specialists dedicated to providing the best care possible. Make an Appointment Call 1.877.CALL.NJH Ask a Question | Insurance Information | Refer a Patient Our Patient Education Program at National Jewish Health provides many free educational opportunities and support groups to assist patients and caregivers with managing illnesses and chronic conditions. Intimacy and the Person with Lung Disease Living with Chronic Disease Managing Your Energy Everyday Managing Your Lung Disease Nutrition and the Person With Lung Disease Stress Management and Relaxation Supporting Each Other Together (A support group for people living with chronic disease.) Tools for Giving-Up Smoking - Trying Again Understanding Your Lung Disease and Testing Download Free Patient Education Materials There are a number of written materials to support patient education at National Jewish Health. They include Understanding Booklets, Med Facts, Test Facts, Medication handouts and more. Free Education Materials Treatment Locations National Jewish Health Main Campus View all locations Reasons to Visit The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses Ranked as one of the top two hospitals in pulmonology every year since U.S. News & World Report included this category in its annual “Best Hospitals” survey Ranked in the top 1 percent of hospitals in the nation by HCAHPS Physicians frequently recognized as among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly Among the top 8 percent of organizations funded for research by the NIH, providing patients access to the latest clinical trials 120 -year history of focus on care, research and education serving thousands of patients with lung, heart, immune and related disorders Make an Appointment Ask a Question | Insurance Information Many patients who come to National Jewish Health are trying to find answers to ongoing health issues. Our doctors use advanced testing to accurately diagnose our patients’ conditions and determine the best treatment plan. CT Scan of the Chest Pulmonary Function Tests You can support National Jewish Health in a variety of ways. Learn about more ways to give to help us provide lifesaving care and groundbreaking research. Make a Donation Living with COPD COPD: Additional Resources Managing Your Environment COPD: Life Skills Tutorial See More Clinical Trials Investigational Medication for AATD & COPD Do you have alpha-1 with emphysema? Our researchers want to learn if an investigational medication, a hyaluronic acid inhalation solution, can be used to treat adults who have alpha-1 antitrypsin deficiency (AATD) with emphysema. Learn More View More Clinical Trials Patient Stories Living the Sweet Life with Alpha-1 Judy got the test for Alpha-1, and it came back positive. She began weekly augmentation therapy at National Jewish Health and has felt a great relief of her symptoms. Read More View All Patient Stories Make an Appointment Call 1.877.CALL.NJH
Clinical Trials Investigational Medication for AATD & COPD Do you have alpha-1 with emphysema? Our researchers want to learn if an investigational medication, a hyaluronic acid inhalation solution, can be used to treat adults who have alpha-1 antitrypsin deficiency (AATD) with emphysema. Learn More View More Clinical Trials
Patient Stories Living the Sweet Life with Alpha-1 Judy got the test for Alpha-1, and it came back positive. She began weekly augmentation therapy at National Jewish Health and has felt a great relief of her symptoms. Read More View All Patient Stories
Sign Up Today! Our monthly newsletter includes expert health tips, recent research findings, and news from National Jewish Health. Go Submitting...