Alpha-1 Antitrypsin Deficiency Make an Appointment Refer a Patient Ask a Question Make an Appointment Refer a Patient Ask a Question Alpha-1 Antitrypsin Deficiency (often called simply “Alpha-1”) is an inherited condition that can cause liver disease in people of all ages and can lead to lung disease in adults. Alpha-1 is one of the most common inherited disorders. It accounts for about one percent of all cases of chronic obstructive pulmonary disease (COPD) in the United States. National Jewish Health in Denver, Colorado, is one of the best places in the world to be treated for the adult lung and liver disease caused by Alpha-1. Our program has been devoted to the care of families with Alpha-1 since 1981, and our doctors have been involved in nearly every new drug evaluated for Alpha-1 treatment. Our doctors are researchers too, so you have access to the latest Alpha-1 clinical trials and most effective therapies. Alpha-1 Care at National Jewish Health At National Jewish Health, you’ll find: The latest in clinical trials A focused and integrated approach State-of-the-art diagnostic testing The latest and best therapies Rehabilitation services Continued follow-up to meet your changing needs. Learn more about the Alpha-1 Treatment Program. Condition Information Alpha-1 Antitrypsin Deficiency Overview More Less Asthma Overview Bronchiectasis Overview COPD Overview Emphysema Lung Cancer: Overview Nontuberculous Mycobacteria (NTM) Overview Search Conditions A-Z Programs & Services Alpha-1 Antitrypsin Deficiency Program More Less COPD Program Department of Medicine Division of Pulmonary, Critical Care and Sleep Medicine (Adult) Infectious Diseases Inpatient and Extended Outpatient Program Search Directory Doctors Karina A. Serban, MD + × Karina A. Serban, MD Karina A. Serban, MD, is a pulmonologist at National Jewish Health. Dr. Serban is in the Division of Pulmonary, Critical Care and Sleep Medicine. Assistant Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine View Full Profile Irina Petrache, MD + × Irina Petrache, MD Irina Petrache, MD, is a pulmonologist at National Jewish Health. Dr. Petrache serves as Chief of the Division of Pulmonary, Critical Care and Sleep Medicine. Chief, Division of Pulmonary, Critical Care & Sleep Medicine Professor of Medicine Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Wollowick Chair in COPD Research View Full Profile Robert A. Sandhaus, MD, PhD, FCCP + × Robert A. Sandhaus, MD, PhD, FCCP Robert A. Sandhaus, MD, is a pulmonologist at National Jewish Health. Dr. Sandhaus is in the Division of Pulmonary, Critical Care and Sleep Medicine. Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine View Full Profile James K. O'Brien, MD, FACP, FCCP + × James K. O'Brien, MD, FACP, FCCP James K. O'Brien, MD, is a pulmonologist at National Jewish Health. Dr. O'Brien is in the Section of Critical Care Medicine and Department of Medicine. Assistant Professor Department of Medicine Division of Pulmonary, Critical Care & Sleep Medicine Section of Critical Care Medicine View Full Profile Loading... Find a Doctor Appointments & QuestionsPatient Education& SupportVisitingUsTests& ProceduresWays toGiveWe Are Open and Here for You: Our specialty care clinics for adults and children are open and ready to serve you. Your health is important, and that means taking care of your existing health care issues. Please note that as we schedule appointments, including necessary procedures, we’re taking every precaution possible to ensure it’s safe to see your doctor. Patient Safety & Care Make an Appointment Call 1.877.CALL.NJH Ask a Question | Insurance Information | Refer a Patient Our Patient Education Program at National Jewish Health provides many free educational opportunities and support groups to assist patients and caregivers with managing illnesses and chronic conditions. Download Free Patient Education Materials There are a number of written materials to support patient education at National Jewish Health. They include Understanding Booklets, Med Facts, Test Facts, Medication handouts and more. Free Education Materials Treatment Locations National Jewish Health Main Campus View all locations Reasons to Choose National Jewish Health The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses Ranked as one of the top two hospitals in pulmonology every year since U.S. News & World Report included this category in its annual “Best Hospitals” survey Ranked in the top 1 percent of hospitals in the nation by HCAHPS Physicians consistently recognized among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly Among the top 6 percent of organizations funded for research by the NIH, providing patients access to more than 300 active clinical trials 121-year history of focus on care, research and education serving thousands of patients with lung, heart, immune and related disorders Make an Appointment Ask a Question | Insurance Information Many patients who come to National Jewish Health are trying to find answers to ongoing health issues. Our doctors use advanced testing to accurately diagnose our patients’ conditions and determine the best treatment plan. Search Tests You can support National Jewish Health in a variety of ways. Learn about more ways to give to help us provide lifesaving care and groundbreaking research. Make a Donation Living with COPD How Your Health Improves After the Last Cigarette Better Health Starts After the Last Cigarette Healthy Eating See More Clinical Trials Efficacy and Safety of VX-814 in Alpha 1 PiZZ Genotype Patient Stories Living the Sweet Life with Alpha-1 Judy got the test for Alpha-1, and it came back positive. She began weekly augmentation therapy at National Jewish Health and has felt a great relief of her symptoms. Read More View All Patient Stories Make an Appointment Call 1.877.CALL.NJH We Are Open and Here for You × Our specialty care clinics for adults and children are open and ready to serve you. Your health is important, and that means taking care of your existing health care issues. Please note that as we schedule appointments, including necessary procedures, we’re taking every precaution possible to ensure it’s safe to see your doctor. Call 303.398.1355 or make an appointment online. Expanded COVID-19 Testing and Care Available Acute Respiratory Clinics for adults and children, and a Respiratory Recovery Clinic for those recovering from COVID-19 are available. Online Telehealth appointments and in office appointments are always available for our patients in need of care. Drive through appointments for COVID-19 testing – antibody (serology) testing and molecular (swab) testing are available. Antibody testing can be self-scheduled, while molecular and other tests require a doctor’s order. Patient Safety As best practice for all patients, COVID-19 patients are cared for in separate, dedicated units. All staff and providers are required to wear masks and other personal protective equipment, and our facilities are continually cleaned using enhanced sterilization procedures. Patients and visitors are screened upon arrival and are required to wear masks. Patients may have only one visitor accompany them to appointments. Please bring your own face mask to wear (cannot be a bandana or scarf, but can be a cloth mask). Coronavirus Information & Resources Close
Clinical Trials Efficacy and Safety of VX-814 in Alpha 1 PiZZ Genotype Patient Stories Living the Sweet Life with Alpha-1 Judy got the test for Alpha-1, and it came back positive. She began weekly augmentation therapy at National Jewish Health and has felt a great relief of her symptoms. Read More View All Patient Stories
Patient Stories Living the Sweet Life with Alpha-1 Judy got the test for Alpha-1, and it came back positive. She began weekly augmentation therapy at National Jewish Health and has felt a great relief of her symptoms. Read More View All Patient Stories