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Allergy Shots (Immunotherapy)

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This information was reviewed and approved by Carah Santos, MD (12/5/2022).

Subcutaneous immunotherapy (commonly called allergy shots) is a form of treatment to reduce an allergic reaction to allergens. Allergy shots consist of a series of injections (shots) with a solution containing the allergens that cause your symptoms. There are usually two phases: buildup and maintenance. Treatment buildup begins with a weak solution given once or twice a week. The strength of the solution is gradually increased with each dose. Once the strongest dosage is reached in a few months, the injections are slowly spaced apart until they reach a frequency of once a month. At that point, sensitivity to the allergens has been decreased and a person has reached a maintenance level. Monthly doses are recommended to continue for at least 3-5 years.

Though not a cure for everyone, allergy shots can significantly reduce allergy symptoms in people who are unable to avoid allergens and who do not respond well to other medications.

Allergy shots should always be given at your health care provider's office since there is a risk of a severe reaction.

Research has shown that allergy shots can reduce symptoms of:

Allergy shots are less effective against molds and are not a useful method for the treatment of food allergies.


When To Consider Immunotherapy

If you are thinking of allergy shots, ask your health care provider about a referral to a board-certified allergist. A board-certified allergist will follow a number of steps to evaluate if allergy shots are right for you.

  1. The allergist will ask you questions about your history, environment and symptoms. This will help determine if skin testing is needed. Prick skin testing may be done. This will help identify the specific allergens that are causing your symptoms. Skin testing should only be done under the supervision of a board-certified allergist.
  2. Once an allergy has been identified, the next step is to decrease or eliminate exposure to the allergen. This is called avoidance of allergen exposure or environmental control. Evidence shows that allergy and asthma symptoms may improve over time if the recommended environmental control changes are made. For example, removing furry or feathered pets or following control measures for house dust mites and cockroaches may decrease symptoms. Preventing your contact with grasses, weeds and tree pollen may be more difficult. Closing outside doors and windows and using air conditioning decreases exposure in the home.
  3. Next, your allergist may recommend medication. Antihistamines and nasal medications may be recommended. Allergy shots may be recommended for people with severe hay fever. Allergy shots may also be recommended for people with allergic asthma when the allergen cannot be avoided. Allergy shots and sublingual tablets should be prescribed only by a board-certified allergist.


Length of Time

Six months to a year of allergy shots may be required before you notice any improvement in symptoms. If your symptoms do not improve after this time, ask you allergist to review your overall treatment program. In general, allergy shots should be stopped if they are not effective within 2-3 years.

If the treatment is effective, the shots often continue for at least 3-5 years, until the person is symptom-free or until symptoms can be controlled with mild medications. After stopping, some individuals may have a return of symptoms. You should discuss this with your allergist to design an individual treatment program that optimizes your goals.


"Rush Immunotherapy"

"Rush immunotherapy" is a series of allergy shots given over 2-3 consecutive days. This "rushes" the initial buildup phase of the treatment. Increasing doses of allergen extract are given every 30 minutes to hourly instead of every few days or weeks. There is an increased risk of a reaction with this procedure. Therefore, rush immunotherapy should only be done in a hospital or high-risk procedure area under very close supervision.



There are a number of alternative treatments that claim to "cure" allergies. These methods are not supported by scientific studies, nor are they approved by the American Academy of Allergy, Asthma & Immunology. Unapproved alternative treatments include:

  • High-dose vitamin and mineral therapy
  • Urine ingestion or injections
  • Bacterial vaccines
  • Exotic diets
  • Liquid sublingual therapy

It can be easy to feel overwhelmed or confused by the many different methods of allergy testing and treatment. Some treatment strategies are undergoing vigorous scientific evaluation in clinical trials here at National Jewish Health and around the world, but they are not yet proven in safety and efficacy.


It is best to work with a board-certified allergist to evaluate and determine what is appropriate for you.

For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.