The Pathology Laboratory is a Morphology Core Facility, which provides histopathological and immunocytochemical support for clinicians and research investigators at National Jewish Health.
The facility provides quality control for morphologic studies, and optimizes use of supplies and equipment. Ongoing interaction of our personnel with each investigator facilitates communication regarding morphologic findings, histopathological interpretation, and new technical developments, thus increasing the efficiency of the research projects.
Our personnel are experienced, dedicated technicians who are accustomed to serving specialized clinical and research needs. A full range of histologic routine and special staining procedures are available. Immunohistochemistry techniques also are offered. Expert advice is available regarding optimal staining methods for special projects.
Areas of Research and Clinical Pathology
Our areas of expertise include, but are not limited to:
Clinical Pathology - evaluation of bronchial biopsies, nasal biopsies and intestinal tract samples for light level abnormalities
Experimental Pathology - animal models of inflammation and pathologic states and in human pulmonary diseases We have extensive experience in the evaluation of development and resolution of pulmonary inflammation, fibrosis, and in animal "models" of asthma. In the past ten years we have also explored the involvement of chronic infection with atypical pathogens in the persistence of asthma. We have a long-standing interest in pulmonary vascular remodeling in pulmonary hypertension.
Cell Biology Experimental responses of macrophages and neutrophils to mediators of inflammation. Apoptosis (studies in neutrophils, lymphocytes and epithelial cells).
Major Capital Equipment
Philips 400 T Electron Microscope
Philips CM 10 Electron Microscope
Reichert- Jung Ultracut E ultramicrotomes
Lynx EM Tissue Processor
Miles-Sakura VIP Tissue processor
Miles-Sakura Embedding Center
Reichert -Jung Cryocut Cryostat
Zeiss Light Microscope
Olympus Double-headed Light Microscope Equipped with Camera