Anthony N. Gerber, MD, PhD

Special Interests

Research Interests

The glucocorticoid receptor is one of the most important therapeutic targets for the treatment of inflammatory disorders of the lung such as asthma. My laboratory investigates two aspects of glucocorticoid receptor signaling. First, we are studying the basic molecular mechanisms whereby glucocorticoids repress the expression of inflammatory genes in the airway. Second, we are investigating how various non-inflammatory genes that are regulated by glucocorticoids alter lung function. By defining new mechanisms of glucocorticoid action we ultimately seek to discover new targets for asthma therapeutics.

Board Certification

Internal Medicine
Pulmonary Disease

Professional Memberships

American Thoracic Society
American Physiological Society
American Lung Association of Colorado

Publications

Sasse SK, Gerber AN. Feed-forward transcriptional programming by nuclear receptors: regulatory principles and therapeutic implications. Pharmacol Ther. 2015 Jan;145:85-91. Epub 2014 Feb 5.
 
Sasse SK, Zuo Z, Kadiyala V, Zhang L, Pufall MA, Jain MK, Phang TL, Stormo GD, Gerber AN. Response Element Composition Governs orrelations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops. J Biol Chem. 2015 Aug 7;290(32):19756-69. Epub 2015 Jun 18.
 
Gerber AN. Glucocorticoids and the Lung. Adv Exp Med Biol. 2015;872:279-98.
 
Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proc Natl Acad Sci USA. 2015 Dec 8;112(49):E6780-9. Epub 2105 Nov 23.
  
Kadiyala V, Sasse SK, Altonsy MO, Berman R, Chu HW, Phang TL, Gerber AN. Cistrome-based Cooperation Between Airway Epithelial Glucocorticoid Receptor and NF-kB Orchestrates Anti-inflammatory Effects. J Biol Chem. 2016 Apr 13.

Hospital Affiliations

• Rose Medical Center

Academic Affiliations

Associate Professor of Medicine, University of Colorado Denver
Graduate Faculty, Department of Pharmacology, University of Colorado Denver

Website Information

Conflicts of Interest

National Jewish Health physicians and scientists may collaborate with pharmaceutical or other industries to develop medical and scientific breakthroughs or to provide education on trends in quality medical practice and outcomes to physicians and health professionals around the country. National Jewish Health maintains a strict conflict of interest policy to ensure that all potential conflicts are clearly visible and that management plans are put in place in order to further innovation and education while ensuring the protection of our patients and the integrity of our research. National Jewish Health publicly discloses any payment to our physicians or scientists. View this faculty member’s industry relationships and collaborations.