Sjögren's Syndrome: Diagnosis Make an Appointment Refer a Patient Ask a Question Reviewed by Mehrnaz Maleki, MD (April 01, 2019) It is often difficult to diagnose Sjögren's syndrome. In fact, it may take years before a definite diagnosis is made. A specialist in autoimmune diseases (known as a rheumatologist) is usually required to establish the diagnosis. The diagnosis of Sjögren's syndrome is made based on the careful analysis of many factors. A thorough history and physical examination are essential. Also, there are certain laboratory studies that can be helpful when considering the diagnosis. It is important to note that a diagnosis cannot be made based on any specific blood test alone. In 2016, the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) jointly endorsed a new set of criteria for the classification of primary Sjögren's syndrome (SS) derived through international consensus. These criteria are based on testing of the saliva, blood and eyes. ACR/EULAR classification criteria for primary Sjögren's syndrome Item Weight/Score Saliva Labial salivary gland (salivary glands near the mouth) A focal lymphocytic sialadenitis and focus score of ≥1 3 Unstimulated whole saliva flow rate ≤0.1 ml/minute 1 Blood test Anti-SSA/SSB (Ro) positive (antibodies to Ro/SSA antigen) 1 Eyes Ocular staining (measures damage to the surface of the eye) A score ≥5 (or van Bijsterfeld score ≥4) on at least one eye 1 Schirmer’s test (measures tear production) ≤5 mm/5 minutes on at least one eye 1 The diagnosis of primary Sjögren's syndrome applies to any person who meets the inclusion criteria (has some of these symptoms) and who has a score of four or greater when the weights/scores from the five criteria are totaled. Sjögren's Syndrome: Symptoms Sjögren's Syndrome: Treatment Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.