Sjögren's Syndrome: Associated Conditions Make an Appointment Refer a Patient Ask a Question Reviewed by Mehrnaz Maleki, MD (April 01, 2019) Many people develop Sjögren's syndrome without any other autoimmune conditions. However, it is common to develop Sjögren's syndrome in association with other autoimmune diseases, such as rheumatoid arthritis and lupus. Studies have shown that people with Sjögren's syndrome have a higher risk of developing lymphoma. This is a type of cancer. Also, an antibody (a protein created by the immune system) that may be present in pregnant women with Sjögren's syndrome can cause heart problems in newborns as well as congenital lupus. Sjögren's Syndrome: Treatment Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.