Sjögren's Syndrome: Symptoms Make an Appointment Refer a Patient Ask a Question Reviewed by Mehrnaz Maleki, MD (April 01, 2019) Because Sjögren's syndrome often targets the tear and salivary glands, the most common symptoms involve the eyes and mouth. As an autoimmune disease, the syndrome also has the capability to affect many of the body's other organs and tissues, leading to a wide array of symptoms. Common symptoms of Sjögren's syndrome include: Dryness of the eyes Dryness of the mouth Difficulty swallowing Change in taste Frequent cavities in the teeth Frequent oral yeast infections Swollen salivary glands Vaginal dryness Heartburn Cough Shortness of breath Arthritis Fatigue Depending on the organs and tissues affected, other symptoms also may be present. Sjögren's Syndrome: Causes Sjögren's Syndrome: Diagnosis Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.