Cardiac Sarcoidosis: Diagnosis Make an Appointment Refer a Patient Ask a Question Reviewed by Howard D. Weinberger, MD, FACC (December 01, 2016) How Is Cardiac Sarcoidosis Diagnosed? Diagnosing cardiac sarcoidosis can be very challenging. There are no widely accepted guidelines for either screening or diagnosing sarcoidosis of the heart. Moreover, the current available diagnostic tests are variable in their ability to detect cardiac sarcoidosis. Because of the devastating nature of cardiac sarcoidosis, most people with other forms of sarcoidosis are screened for sarcoidosis of the heart. Initial cardiac evaluation may include an electrocardiogram (EKG), a signal-averaged EKG, an echocardiogram (ultrasound of the heart) and a Holter monitor (extended EKG). Additional imaging tests may include single positron emission computed tomography (SPECT), positron emission tomography (PET), and cardiac MRI. A positive heart biopsy confirms cardiac sarcoidosis, but may more often be negative or normal even when there is sarcoidosis in the heart, especially if heart function is normal. Cardiac Sarcoidosis: Types Cardiac Sarcoidosis: Treatment Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.