Cardiac Sarcoidosis: Treatment Make an Appointment Refer a Patient Ask a Question Reviewed by Howard D. Weinberger, MD, FACC (December 01, 2016) What Is the Treatment for Cardiac Sacoidosis? Controversy exists as to the best treatment for cardiac sarcoidosis. However, treatment is often directed at minimizing the inflammation seen with cardiac sarcoidosis and protecting against the life-threatening complications. Because of their anti-inflammatory properties, corticosteroids (cortisone, prednisone, and methylprednisolone) are the first-line therapy to treat the inflammation. When people cannot take steroids, or when combination therapy is needed, other medications are used. These include: methotrexate, azathioprine, mycophenolate and antimalarials. Additional therapies for specific cardiac sarcoidosis related heart disorders may be necessary. For example, heart rhythm disorders such as complete heart block typically require placement of a permanent pacemaker, whereas ventricular tachycardia generally requires internal cardiac defibrillator (ICD) placement. What Do We Do at National Jewish Health? We provide comprehensive cardiology evaluation and consultation and noninvasive cardiac testing. We evaluate and treat heart problems such as coronary artery disease, high blood pressure, high cholesterol, heart valve problems and heart failure. In addition to traditional heart problems, we offer expertise in many other focus areas, including evaluation of patients with shortness of breath with exercise, sarcoidosis of the heart, diastolic dysfunction and secondary pulmonary hypertension. Cardiac Sarcoidosis: Diagnosis Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.