Cardiac Sarcoidosis: Causes Make an Appointment Refer a Patient Ask a Question Reviewed by Howard D. Weinberger, MD, FACC (December 01, 2016) What Causes Cardiac Sarcoidosis? The exact cause of sarcoidosis is unknown. Granulomas appear to be the result of an immune system response to an unidentified trigger. Infectious agents as well as environmental exposures are thought to be possible precipitants for this immune response; however, no clear triggers or causes of sarcoidosis have been identified. Genetic mutations in white blood cell proteins (called human leukocyte antigens, or HLA) as well as chemicals that control inflammation (called cytokines) have also been linked to sarcoidosis. Cardiac Sarcoidosis: Types Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.