Skip to content

Pulmonary Alveolar Proteinosis (PAP) Program

Pulmonary Alveolar Proteinosis (PAP) is a rare lung disease. In PAP, grainy material builds up in the air sacs (alveoli) of the lungs. This grainy material is made up of substances that normally are part of the coating of the alveoli. Healthy lungs contain a small amount of this material, called surfactant, which normally helps the lungs expand during breathing. However, in PAP, there is excessive buildup of this material, which makes it harder for the lungs to absorb oxygen. This leads to breathing problems, which can be severe. In addition, many PAP patients get secondary infections.

The Pulmonary Alveolar Proteinosis (PAP) program offers comprehensive evaluation and management of PAP. Under our care, people with PAP can lead active lives.


We offer:

  • Rapid initial consultation with physicians who are experts in Pulmonary Alveolar Proteinosis and who have extensive experience treating patients with this rare condition

  • Frequent follow-up with the same physicians

  • Cutting edge diagnostic testing to confirm the diagnosis of PAP and determine its cause

  • Various treatment options tailored to the individual patient and disease severity, including whole lung lavage, inhaled GM-CSF, and immunosuppression if indicated

  • Patient education on the causes of Pulmonary Alveolar Proteinosis

  • Pulmonary rehabilitation programs

  • Care integrated with opportunities to participate in cutting edge research as part of the Rare Lung Diseases Consortium

  • Care integrated with patient support from the Pulmonary Alveolar Proteinosis Foundation.


Other Services:


To make an appointment in the PAP clinic, make an appointment online or call 1.877.CALL.NJH (877.225.5654).


Matthew Koslow

Matthew Koslow, MD

Clinical Trials

For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.

Reasons to Choose National Jewish Health

  • The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses
  • Ranked #1 or #2 in Pulmonology by U.S. News & World Report for 26 consecutive years
  • Ranked in the top 5% of hospitals in the nation by HCAHPS
  • Physicians consistently recognized among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly
  • Among the top 6% of organizations funded for research by the NIH, providing patients access to hundreds of active clinical trials
  • 124-year history of focus on care, research and education serving patients from around the world with lung, heart, immune and related disorders
Make an Appointment