Diagnosis Make an Appointment Refer a Patient Ask a Question Reviewed by Barbara Goldstein, MD (February 01, 2016) It is often difficult to diagnose undifferentiated connective tissue disease (UCTD). A specialist in systemic autoimmune diseases, known as a rheumatologist, is usually required to establish the diagnosis. The diagnosis of UCTD is based on the careful analysis of many factors. A thorough history and physical examination are essential. There are also certain laboratory studies that are helpful when considering the diagnosis. However, it is important to note that the diagnosis cannot be made based on any one specific blood test. The evaluation often includes X-rays of the chest and involved joints, CT scans of the lungs, heart testing and evaluation for problems with the esophagus. Symptoms Treatment Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.