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Trial Objectives

People with eosinophilic granulomatosis with polyangiitis (EGPA) are needed for the OCEAN clinical trial. The study compares two medications:  mepolizumab (NUCALA), which is administered by an injection once a month, and depemokimab, an investigational medication that is injected twice a year. Researchers want to understand if depemokimab is as safe and effective as mepolizumab. Volunteers will receive a blood draw and will be randomly assigned to receive an injection of one of the two medications.

Who Can Participate

Adults with EGPA that has worsened or returned after previous treatment and are taking a corticosteroid or immunosuppressant

Age: 18+ Gender: Any

Estimated Time Commitment

Once a month visits for approximately 15 months

Payment & Reimbursement

Payment: Provided

Travel Reimbursement: Available

Trial Contact

For more information, contact:

Allen Stevens

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Trial Location

National Jewish Main Campus, Denver, CO

Trial Sponsors


Principal Investigators

Michael E. Wechsler

Michael E. Wechsler, MD, MMSc


Vamsi P. Guntur

Vamsi P. Guntur, MD, MSc

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By completing this form, you agree to learn more about this study and see if you qualify.

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