Causes Make an Appointment Refer a Patient Ask a Question Reviewed by the National Digestive Diseases Information Clearinghouse (July 01, 2009) Researchers have yet to discover any specific cause for irritable bowel syndrome (IBS). One theory is that people who suffer from IBS have a colon that is particularly sensitive and reactive to certain foods and stress. The immune system, which fights infection, may also be involved. Normal bowel movement may not be present in the colon of a person who has IBS. It can be spasmodic or can even stop working temporarily. Spasms are sudden strong muscle contractions that come and go. The lining of the colon called the epithelium, which is affected by the immune and nervous systems, regulates the flow of fluids in and out of the colon. In IBS, the epithelium appears to work properly. However, when the contents inside the colon move too quickly, the colon loses its ability to absorb fluids. The result is too much fluid in the stool. In other people, the movement inside the colon is too slow, which causes extra fluid to be absorbed. As a result, a person develops constipation. A person's colon may respond strongly to stimuli such as certain foods or stress that would not bother most people. Recent research has reported that serotonin is linked with normal gastrointestinal (GI) functioning. Serotonin is a neurotransmitter, or chemical, that delivers messages from one part of your body to another. Ninety-five percent of the serotonin in your body is located in the GI tract, and the other five percent is found in the brain. Cells that line the inside of the bowel work as transporters and carry the serotonin out of the GI tract. In the case of people with IBS, there's less receptor activity, causing abnormal levels of serotonin to exist in the GI tract. As a result, they experience problems with bowel movement, motility, and sensation (having more sensitive pain receptors in their GI tract). Researchers have reported that IBS may be caused by a bacterial infection in the gastrointestinal tract. Studies show that people who have had gastroenteritis sometimes develop IBS, otherwise called post-infectious IBS. Studies have also shown very mild celiac disease in some people with symptoms similar to IBS. People with celiac disease cannot digest gluten, a substance found in wheat, rye, and barley. People with celiac disease cannot eat these foods without becoming very sick because their immune system responds by damaging the small intestine. A blood test can determine whether celiac disease may be present. Symptoms Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.