Diagnosis Make an Appointment Refer a Patient Ask a Question Reviewed by Mehrnaz Maleki, MD (September 01, 2019) It is often difficult to diagnose scleroderma (systemic sclerosis) . A specialist in autoimmune diseases is often required to establish the diagnosis. This specialist is a rheumatologist. The diagnosis of scleroderma is made based on the careful analysis of many factors. A thorough history and physical examination are essential. There are also certain laboratory studies that can be helpful when considering the diagnosis. These may include specific blood and urine tests. Other tests, including specialized lung and heart evaluations, are needed to determine if there is any internal organ involvement from scleroderma. It is important to note that a diagnosis cannot be made based on any specific blood test alone. Symptoms Treatment Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.