Pulmonary Embolism Make an Appointment Find a Doctor Ask a Question Reviewed by the National Heart Lung and Blood Institute (August 01, 2009) A pulmonary embolism, or PE, is a sudden blockage in a lung artery, usually due to a blood clot that traveled to the lung from a vein in the leg. A clot that forms in one part of the body and travels in the bloodstream to another part of the body is called an embolus. PE is a serious condition that can cause permanent damage to part of your lung from lack of blood flow to lung tissue, low oxygen levels in your blood, and even damage to other organs in your body from not getting enough oxygen. If the blood clot is large, or if there are many clots, PE can even cause death. In most cases, PE is a complication of a condition called deep vein thrombosis (DVT). In DVT, blood clots form in the deep veins of the body (most often in the legs). These clots can break free, travel through the bloodstream to the lungs, and block an artery. This is unlike clots in the veins close to the skin's surface, which remain in place and do not cause PE. At least 100,000 cases of PE occur each year in the United States. PE is the third most common cause of death in hospitalized patients. If left untreated, about 30 percent of patients with PE will die. Most of those who die do so within the first few hours of the event. Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.