Leukotriene Modifiers Make an Appointment Ask a Question Search Conditions Leukotriene modifiers are long-term asthma control medications. They reduce swelling inside the airways and relax smooth muscles around the airways. Leukotriene modifiers are available as pills and liquids. They are effective at improving asthma symptoms and lung function, but not to the same extent as inhaled steroids. Common leukotriene modifiers include: Medicine Name How the Medicine Works How the Medicine is Used Accolate® (zafirlukast) Singulair® (montelukast) Zyflo® (zileuton) Reduces inflammation inside the airways Relaxes the smooth muscles around the airways Available as pills, syrup Prescribed to take 1-2 times every day Can interact with other medicines This information has been approved by Ronina Covar, MD and Ann Mullen, RN, MSN, CNS, AE-C (December, 2012).