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Medicines That Can Cause Insomnia

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This information was reviewed and approved by Sheila Tsai, MD (3/1/2017).

A number of medications can cause insomnia. 

If you take any of the following medicines and are having sleep disruptions, talk with your doctor. Do not stop any medicines if you have not consulted with your doctor. Medications that can cause insomnia include:


  • Selective serotonin reuptake inhibitors (antidepressants such as Prozac® and Zoloft®)

  • Dopamine agonists (includes some medications for Parkinson's disease)

  • Psychostimulants and amphetamines

  • Anticonvulsants

  • Cold medicines and decongestants

  • Steroids

  • Beta agonists

  • Theophylline

  • Medications to lower blood pressure (alpha agonists, beta blockers)

  • Diuretics

  • Appetite suppressants

  • Caffeine

  • Alcohol

  • Niacin

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