Food Protein Induced Enterocolitis Syndrome (FPIES)

Reviewed by Bruce J. Lanser, MD

FPIES is an uncommon adverse GI reaction to a particular food. It is different from more common food allergies like IgE mediated food allergy. The exact mechanism is not clearly understood. Patients typically experience symptoms before 1 year of age, and it often can be difficult for providers to diagnose until a few episodes have occurred. The reactions almost always include profuse vomiting, a few hours after eating a trigger food. The child can also be lethargic, have cool or clammy skin, and look very sick.

FPIES affects less than 0.5% of the population. Reactions to new foods are uncommon after the first year of life. FPIES can be outgrown within a few years, but certain foods may persist longer. The treatment for FPIES involves strict avoidance of the trigger food, and often a special dietary plan for introducing new foods. Your child’s allergist will typically work closely with a nutritionist to help make this plan, and monitor growth and nutrition. Sometimes it may be necessary to also work with a feeding therapist.


Most Common FPIES Foods

  • Milk
  • Soy
  • Oat
  • Rice


Other Common FPIES Foods

  • Legumes (peas, beans, lentils)
  • Poultry (chicken and turkey)
  • Egg
  • Fish and Shellfish
  • Banana
  • Sweet Potato (*not white potato)
  • Wheat


Our Specialists

  • Bruce J. Lanser
    Bruce J. Lanser, MD

Clinical Trials

For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.