Symptoms Make an Appointment Refer a Patient Ask a Question Reviewed by Andrew M. Freeman, MD, FACC, FACP (June 01, 2019) What are the Symptoms of Coronary Artery Disease (CAD)? CAD makes it more difficult for oxygen-rich blood to move through arteries. Common symptoms of CAD include: Angina: Upper body pain or pressure. It's usually felt in the chest, but can also be experienced in the back, belly, and even the jaw Shortness of breath: Shortness of breath (dyspnea) with exertion, or chest tightness, squeezing, or burning. Sometimes CAD has no symptoms, called silent CAD. It can go undiagnosed up until someone has a heart attack, irregular heartbeat or other heart conditions. Diagnosis Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.