Beryllium Sensitization Make an Appointment Find a Doctor Ask a Question Reviewed by Lisa A. Maier, MD, MSPH, FCCP (July 01, 2021) About Beryllium Sensitization Beryllium sensitization is an allergy to beryllium that may develop after a susceptible person breathes beryllium dust or fumes, or if beryllium penetrates the skin through an open cut or skin exposure. Individuals that have a certain gene called HLA-DPB Glu69 are susceptible and more likely to become sensitized after exposure to beryllium. In individuals with beryllium sensitization, the immune system thinks beryllium is a “foreign substance” and sends immune cells into the bloodstream that react to the beryllium. These cells can be found in the blood using a test called the beryllium lymphocyte proliferation test (BeLPT). Programs & Services Beryllium Program Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.