Publications
1. Boguniewicz M, Leung DY. "Recent insights into atopic dermatitis and implications for management of infectious complications." Journal of Allergy and Clinical Immunology. 2010 Jan;125(1):4-13. PMCID: PMC28148072. http://www.ncbi.nlm.nih.gov/pubmed/20109729
2. Grigoryev DN, Howell MD, Watkins T, Chen Y-C, Cheadle C, Boguniewicz M, Barnes KC, Leung DY. “Vaccinia Virus-Specific Molecular Signature in Atopic Dermatitis Skin.” Journal of Allergy and Clinical Immunology, 2010 Jan; 125(1): 153-159. PMCID: PMC2814071. http://www.ncbi.nlm.nih.gov/pubmed/20109744.
3. Schlievert PM, Strandberg KL, Lin YC, Peterson ML, Leung DL. "Secreted virulence factor comparison between methicillin-resistant and methicillin-sensitive Staphylococcus aureus, and its relevance to atopic dermatitis." Journal of Allergy and Clinical Immunology. 2010 Jan;125(1):39-49. PMCID: PMC2814367. http://www.ncbi.nlm.nih.gov/pubmed/20109735.
4. Liu L, Zhong Q, Tian T, Dubin K, Athale SK, Kupper TS. “Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity.” Nature Medicine; 2010 Feb; 16(2):224-7. PMCID: PMC3070948. http://www.ncbi.nlm.nih.gov/pubmed/20081864.
5. Gao PS, Rafaels NM, Mu D, Hand T, Murray T, Boguniewicz M, Hata T, Schneider L, Hanifin JM, Gallo RL, Gao L, Beaty TH, Beck LA, Leung DYM, Barnes KC. “Genetic variants in TSLP are associated with atopic dermatitis and eczema herpeticum.” Journal of Allergy and Clinical Immunology, 2010 Jun; 125(6): 1403-1407. PMCID: PMC2925504. http://www.ncbi.nlm.nih.gov/pubmed/20466416
6. Freyschmidt EJ, Mathias CB, MacArthur DH, Laouar A, Manjunath N, Hofer M, Wurbel M-A, Campbell J, Chatila T, Oettgen HC. “Skin inflammation arising from Cutaneous Treg deficiency leads to Impaired viral immune responses.” Journal of Immunology, 2010 Jul; 185(2): 1295-1302. PMCID: PMC3873154. http://www.ncbi.nlm.nih.gov/pubmed/20548030
7. Hata T, Kotol P, Boguniewicz M, Taylor P, Paik A, Jackson M, Nguyen M, Kabigting F, Miller J, Gerber M, Zaccaro D, Armstrong B, Dorschner R, Leung DY, Gallo RL. “History of Eczema Herpeticum is associated with the inability to induce HBD-2, HBD-3 and cathelicidin in the skin of patients with atopic dermatitis.” The British Journal of Dermatology; 2010 Sep; 163(3): 659-661. PMCID: PMC2966528. http://www.ncbi.nlm.nih.gov/pubmed/20545685
8. He R, Oyoshi MK, Wang JYT, Hodge MR, Jin H, and Geha RS. “The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation following epicutaneous antigen challenge.” Journal of Allergy and Clinical Immunology; 2010 Oct; 126(4): 784-790. PMCID: PMC2950231. http://www.ncbi.nlm.nih.gov/pubmed/20713302
9. Oyoshi MK, Larson RP, Ziegler SF, and Geha RS. “Mechanical injury polarizes skin dendritic cells to elicit a Th2 response by inducing cutaneous TSLP expression.” Journal of Allergy and Clinical Immunology; 2010 Nov; 126(5): 976-984. PMCID: PMC3085022. http://www.ncbi.nlm.nih.gov/pubmed/21050944
10. Hammarlund E, Lewis MW, Hanifin J, Motomi M, Koudelka CW, Slifka MK. "Antiviral immunity following smallpox virus infection: a case-control study." Journal of Virology. 2010 Dec;84(24): 12754-60. PMCID: PMC3004327. http://www.ncbi.nlm.nih.gov/pubmed/20926574
11. Schneider L, Weinberg A, Boguniewicz M, Taylor P, Oettgen H, Heughan L, Zaccaro D, Armstrong B, Holliday A, Leung DYM. “Immune response to Varicella vaccine in children with atopic dermatitis compared to non-atopic controls.” Journal of Allergy and Clinical Immunology, 2010 Dec; 126(6); 1306-13-7. PMCID: PMC2998561. http://www.ncbi.nlm.nih.gov/pubmed/20889193
12. Broccardo C, Mahaffey S, Schwarz J, Wruck L, David G, Schlievert P, Reisdorph N, Leung D. “Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization.” Journal of Allergy and Clinical Immunology; 2011 Jan; 127(1): 186-93, 193.e1-11. PMCID: PMC3059191. http://www.ncbi.nlm.nih.gov/pubmed/21211653
13. Bin L, Howell M, Kim B, Streib J, Hall C, Leung D. “Specificity Protein 1 is Pivotal in the Skin’s Antiviral Response.” Journal of Allergy and Clinical Immunology. 2011 Feb; 127(2): 430-438. PMCID: PMC3734863. http://www.ncbi.nlm.nih.gov/pubmed/21208652
14. De Benedetto A, Rafaels NM, McGirt LY, Ivanov AI, Georas SN, Cheadle C, Berger A, Boguniewicz M, Hata T, Schneider LM, Hanifin JM, Gallo RL, Weidinger S, Beaty TH, Leung DY, Barnes KC, Beck LA. “Tight Junction Defects in Patients with Atopic Dermatitis.” Journal of Allergy and Clinical Immunology, 2011 Mar; 127(3): 773-786. PMCID: PMC3049863. http://www.ncbi.nlm.nih.gov/pubmed/21163515
15. Leung D, Gao P, Grigoryev D, Rafaels N, Strieb J, Howell M, Taylor P, Boguniewicz M, Canniff J, Armstrong B, Zaccaro D, Schneider L, Hata T, Hanifin J, Beck L, Weinberg A, Barnes K. “Human Atopic Dermatitis Complicated by Eczema Herpeticum is Associated with Abnormalities in Gamma Interferon Response.” Journal of Allergy and Clinical Immunology; 2011 Apr; 127(4): 965-73. PMCID: PMC3074534. http://www.ncbi.nlm.nih.gov/pubmed/21458658
16. Oyoshi MK, ElKhal A, Scott JE, Wurbel M, Hornick JL, Campbell JJ, and Geha RS. “Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin.” Journal of Clinical Investigation; 2011 Jun; 121(6): 2210-2220. PMCID: PMC3105371. http://www.ncbi.nlm.nih.gov/pubmed/21537081
17. Boguniewicz M, Leung DYM. "Atopic dermatitis: a disease of altered skin barrier and immune dysregulation." Immunological Reviews. 2011 Jul;242(1):233-46. PMCID: PMC3122139. http://www.ncbi.nlm.nih.gov/pubmed/21682749
18. De Benedetto A, Slifka M, Rafaels N, Kuo I, Georas S, Boguniewicz M, Hata T, Schneider L, Hanifin J, Gallo R, Paller A, Johnson D, Barnes K, Leung D, Beck L. “Reductions in Claudin-1 may enhance susceptibility to HSV-1 infections in atopic dermatitis.” Journal of Allergy and Clinical Immunology; 2011 Jul; 128(1): 242-246. PMCID: PMC3129463. http://www.ncbi.nlm.nih.gov/pubmed/21489616
19. Hinz T, Zaccaro D, Byron M, Brendes K, Krieg T, Novak N, Bieber T. “Atopic Dermo-Respiratory Syndrome Is a Correlate of Eczema Herpeticum.” Allergy; 2011 Jul; 66(7): 925-33. PMCID: PMC3082611. http://www.ncbi.nlm.nih.gov/pubmed/21255038
20. Milgrom H, Kesler K, Byron M, Harbeck R, Holliday R, Leung DYM. “Response to cutaneous immunization with low molecular weight subunit keyhole limpet hemocyanin (KLH).” International Archives of Allergy and Immunology; 2011 Oct 28; 157(3): 269-274. PMCID: PMC3224512. http://www.ncbi.nlm.nih.gov/pubmed/22042247
21. Oyoshi MK, Wang JYT, and Geha RS. “Immunization with modified vaccinia virus Ankara prevents eczema vaccinatum in a murine model of atopic dermatitis.” Journal of Allergy and Clinical Immunology; 2011 Oct; 128(4): 890-892. PMCID: PMC3185136. http://www.ncbi.nlm.nih.gov/pubmed/21820712
22. Bin L, Howell MD, Kim BE, Streib JE, Leung DYM. “Inhibition of Transcription Factor Specificity Protein 1 Alters the Gene Expression Profile of Keratinocytes Leading to Upregulation of Kallikrein-Related Peptidases and Thymic Stromal Lymphopoietin.” Journal of Investigative Dermatology; 2011 Nov; 131(11): 2213-22. PMCID: PMC3193562. http://www.ncbi.nlm.nih.gov/pubmed/21753780
23. Howell M, Gao P, Kim B, Lesley L, Streib J, Taylor P, Zaccaro D, Boguniewicz M, Beck L, Hanifin J, Schneider L, Hata T, Gallo R, Kaplan M, Barnes K, Leung D. “The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections.” Journal of Allergy and Clinical Immunology; 2011 Nov; 128(5): 1006-14. PMCID: PMC3205328. http://www.ncbi.nlm.nih.gov/pubmed/21762972
24. Novak N, Leung DYM. "Advances in atopic dermatitis." Current Opinion in Immunology. 2011 Dec;23(6):778-83. PMCID: PMC3232325. http://www.ncbi.nlm.nih.gov/pubmed/22018455
25. Domenico J, Lucas JJ, Fujita M, Gelfand EW. “Susceptibility to Vaccinia Virus Infection and Spread is Determined by Age at Infection, Allergen Sensitization and Mast Cell Status.” International Archives of Allergy and Immunology, 2012 Jan; 158(2): 196-205. PMCID: PMC3291886. http://www.ncbi.nlm.nih.gov/pubmed/22286752
26. De Benedetto A, Kubo A, Beck LA. “Skin Barrier Disruption – A Requirement for Allergen Sensitization.” Journal of Investigative Dermatology 2012 Mar; 132: 949-963. PMCID: PMC3279586. http://www.ncbi.nlm.nih.gov/pubmed/22217737
27. Gao PS, Leung DY, Rafaels NM, Boguniewicz M, hand T, Gao L, Hata TR, Schneider LC, Hanifin JM, Beaty TH, Beck LA, Weinberg A, Barnes KC. “Genetic Variants in Interferon Regulatory Factor 2 (IRF2) Are Associated with Atopic Dermatitis and Eczema Herpeticum.” Journal of Investigative Dermatology, 2012 Mar; 132 (3 Pt 1): 650-7. PMCID: PMC3278591. http://www.ncbi.nlm.nih.gov/pubmed/22113474
28. Oyoshi MK, Ramesh N, Geha RS. “Vaccinia immune globulin ameliorates eczema vaccinatum in a murine model of atopic dermatitis.” Journal of Investigative Dermatology 2012 April; 132(4): 1299-301. PMCID: PMC3583535. http://www.ncbi.nlm.nih.gov/pubmed/22189790
29. De Benedetto A, Yoshida T, Kuo I, Rafaels N, Boguniewicz, Hata T, Schneider L, Hanifin J, Gallo R, Leung D, Barnes K, Beck L. “Connexin-26 is upregulated in atopic dermatitis epidermis.” Journal of Investigative Dermatology. 2012 May; 132(S1): S51-64 . http://www.nature.com/jid/journal/v132/n1s/full/jid201283a.html
30. Muehleisen B, Bickle DD, Aguilera C, Burton DW, Deftos LJ, Gallo RL. “Vitamin D and PTH/PTHrP alter antimicrobial expression and susceptibility to bacterial skin infection.” Science Translational Medicine. 2012 May; 4(135): 135ra66. PMCID: PMC3725981. http://www.ncbi.nlm.nih.gov/pubmed/22623742
31. Gallo RL, Hooper LV. "Epithelial antimicrobial defence of the skin and intestine." Nature Reviews Immunology. 2012 Jun 25;12(7):503-516. PMCID: PMC3563335. http://www.ncbi.nlm.nih.gov/pubmed/22728527
32. Denby KS, Beck LA. "Update on systemic therapies for atopic dermatitis." Current Opinion in Allergy and Clinical Immunology. 2012 Aug; 12(4): 421-6. PMCID - Not available. http://www.ncbi.nlm.nih.gov/pubmed/22622476
33. Bin L, Kim BE, Brauweiler A, Goleva E, Streib J, Ji Y, Schlievert PM, Leung DY. “Staphylococcus aureus a-toxin modulates skin host response to viral infection.” Journal of Allergy and Clinical Immunology. 2012 Sep; 130(3): 683-691. PMCID: PMC3594992. http://www.ncbi.nlm.nih.gov/pubmed/?term=22840852
34. Oyoshi MK, He R, Li Y, Mondal S, Yoon J, Afshar R, Chen M, Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF, Geha RS. “Leukotriene B4 Driven Neutrophil Recruitment to the Skin is Essential for Allergic Skin Inflammation.” Immunity. 2012 Oct 19;37(4):747-58. PMCID: PMC3478399. http://www.ncbi.nlm.nih.gov/pubmed/23063331
35. Brauweiler AM, Bin L, Kim BE, Oyoshi MK, Geha RS, Goleva E, Leung DY. “Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal a-toxin-induced keratinocyte death.” Journal of Allergy and Clinical Immunology. 2013 Feb;131(2):421-7. PMCID: PMC3742335. http://www.ncbi.nlm.nih.gov/pubmed/23246020
36. Kuo IH, Yoshida T, Beck LA. "The cutaneous innate immune response in patients with atopic dermatitis." Journal of Allergy and Clinical Immunology. 2013 Feb; 131(2):266-78. PMCID - Not available. http://www.ncbi.nlm.nih.gov/pubmed/23374259
37. Kuo IH, Carpenter-Mendini A, Yoshida T, McGirt LY, Ivanov AI, Barnes KC, Gallo RL, Borkowski AW, Yamsaki K, Leung DY, Georas SN, De Benedetto A, Beck LA. “Epidermal toll-like receptor 2 activation enhances tight Junction function and this effect may be reduced in subjects with atopic dermatitis.” Journal of Investigative Dermatology. 2013 Apr;133(4):988-98. PMCID: PMC3600383. http://www.ncbi.nlm.nih.gov/pubmed/23223142
38. Leisten S, Oyoshi MK, Hornick JL, Geha RS. “Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity.” Journal of Allergy and Clinical Immunology. 2013 Apr;131(4):1247-50. PMCID – Not Available. http://www.ncbi.nlm.nih.gov/pubmed/23540619
39. Hata T, Kotol P, Kabigting F, Miller J, Alexandrescu D, Boguniewicz M, Taylor P, Aertker L, Kesler K, Hanifin J, Leung DYM, Gallo RL. “A Randomized Controlled Double Blind Investigation of the Effects of Vitamin D Dietary Supplementation in Subjects with Atopic Dermatitis.” Journal of European Academy of Dermatology and Venereology. 2013 May. PMCID: PMC3769441. http://www.ncbi.nlm.nih.gov/pubmed/23638978
40. Kim BE, Bin L, Leung DYM. “IL-25 Enhances HSV-1 Replication by Inhibiting Filaggrin Expression, and Acts Synergistically with Th2 Cytokines to Enhance HSV-1 Replication.” Journal of Investigative Dermatology. Journal of Investigative Dermatology, 2013 May. PMCID: PMC3785566. http://www.ncbi.nlm.nih.gov/pubmed/23657503
41. Leung DY. “Why is excema herpeticum unexpectedly rare?” Antiviral Research. 2013 May;98(2):153-7. PMCID: PMC3773952. http://www.ncbi.nlm.nih.gov/pubmed/23439082
42. Zhang Y, Leung DY, Goleva E. “Vitamin D enhances glucocorticoid action in human monocytes: involvement of granulocyte-macrophage colony-stimulationg factor and mediator complex subunit 14.” Journal of Biochemistry. 2013 May 17;288(20):14544-53. PMCID: PMC3656308. http://www.ncbi.nlm.nih.gov/pubmed/23572530
43. De Benedetto A, Yoshida T, Kuo I, Gestios S, Ivanov A, Leung DY, Beck LA. "Antagonistic effects of IL-17A and IL-4 on epidermal tight junctions." Journal of Investigative Dermatology. 2013 May; 133: S118. http://www.nature.com/jid/journal/v133/n1s/full/jid201399a.html
44. Afshar M, Martinez AD, Gallo RL, Hata TR. "Induction and exacerbation of psoriasis with Interferon-alpha therapy for hepatitis C: a review and analysis of 36 cases." Journal of European Academy of Dermatology and Venereology. 2013 Jun;27(6):771-8. PMCID: PMC3443510. http://www.ncbi.nlm.nih.gov/pubmed/22671985
45. Leung DY. “New insights into atopic dermatitis: role of skin barrier and immune dysregulation.” Allergology International. 2013 Jun;62(2): 151-61. PMCID - Not Available. http://www.ncbi.nlm.nih.gov/pubmed/23712284
46. MacLeod DT, Nakatsuji T, Yamasaki K, Kobzik L, Gallo RL. HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection. Nat Commun 2013 Jul;4:1963. PMCID: PMC3681428. http://www.ncbi.nlm.nih.gov/pubmed/23739639
47. Spaulding AR, Salgado-Pabon W, Kohler PL, Horswill AR, Leung DY, Schlievert PM. “Staphylococcal and streptococcal superantigen exotoxins.” Clinical Microbiology Reviews. 2013 Jul;26(3): 422-47. PMCID: PMC3719495. http://www.ncbi.nlm.nih.gov/pubmed/23824366
48. Boguniewicz M, Leung DYM. “The ABC’s of managing patients with severe atopic dermatitis.” Journal of Allergy and Clinical Immunology. Aug 2013. 132(2): 511-512. PMCID: PMC3785088. http://www.ncbi.nlm.nih.gov/pubmed/23739639
49. Kumar L, Lu B, Gerard C, Geha RS. “C3a receptor promotes viral containment in mice inoculated with vaccinia virus at sites of allergic skin inflammation” Journal of Allergy and Clinical Immunology. 2013 Sep; 132(3):746-748. PMCID – Not Available. http://www.ncbi.nlm.nih.gov/pubmed/23684067
50. Mathias RA, Weinberg A, Boguniewicz M, Zaccaro DJ, Armstrong B, Schneider LC, Hata TR, Hanifin JM, Beck LA, Barnes KC, Leung DYM. “Atopic Dermatitis Complicated by Eczema Herpeticum is Associated with HLA B7 and Reduced Gamma Interferon Producing CD8+ T Cells.” British Journal of Dermatology. 2013 Sep; 169(3):700-3. PMCID – Not Available. http://www.ncbi.nlm.nih.gov/pubmed/23600999
51. Ando T, Matsumoto K, Namiranian S, Yamashita H, Glatthorn H, Kimura M, Dolan B, Lee JJ, Kawakami Y, Jamora C, Kawakami T. “T cells and mast cells are required for allergen/staphylococcal enterotoxin B- induced skin inflammation.” Journal of Investigative Dermatology. 2013 Dec; 133(12): 2695-708. PMCID: PMC3830701. http://www.ncbi.nlm.nih.gov/pubmed/23752044
52. Slifka MK, Leung DYM, Hammarlund E, Raue HP, Simpson EL, Tofte S, Baig-Lewis S, David G, Lynn H, Woolson R, Hata T, Milgrom H, Hanifin J. “Transcutaneous yellow fever vaccination of subjects with or without atopic dermatitis.” Journal of Allergy and Clinical Immunology. 2014 Feb; 133(2): 439-47. PMCID: PMC3960337. http://www.ncbi.nlm.nih.gov/pubmed/24331381
53. Darling AR, Freyschmidt EJ, Burton OT, Koleoglou KJ, Oyoshi MK, Oettgen HC. "IL-10 suppresses IL-17 mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum." Clinical Immunology. 2014 Feb; 150(2): 153-60. PMCID: PMC3946343. http://www.ncbi.nlm.nih.gov/pubmed/24412909
54. Ando T, Xiao W, Gao PS, Namiranian S, Matsumoto K, Tomimore Y, Hong H, Yamashita H, Kimura M, Kashiwakura J, Hata TR, Izuhara K, Gurish MF, Roers A, Rafaels NM, Barnes KC, Jamora C, Kawakami Y, Kawakami T. "Critical role for mast-cell Stat5 activity in skin inflammation." Cell Reports. 2014 Jan 30;6(2):366-376. PMCID – PMCID: PMC4329986. http://www.ncbi.nlm.nih.gov/pubmed/24412367
55. Bin L, Edwards MG, Heiser R, Streib J, Richers B, Hall C, Leung DYM. Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum. Journal of Allergy and Clinical Immunology. 2014 Oct;134(4):848-55. PMCID: PMC4186924. http://www.ncbi.nlm.nih.gov/pubmed/25159465
56. Leung D, Guttman-Yassky E. "Deciphering the complexities of atopic dermatitis: Shifting paradigms in treatment approaches." Journal of Allergy and Clinical Immunology. 2014 Oct;134(4):769-779. PMCIDL PMC4186710. http://www.ncbi.nlm.nih.gov/pubmed/25282559
57. MacLeod D, Nakatsuji T, Wang Z, di Nardo A, Gallo RL. "Vaccinia Virus Binds to the Scavenger Receptor MARCO on the Surface of Keratinocytes." Journal of Investigative Dermatology. 2015 Jan;135(1): 142-50. PMCID: 4268046. http://www.ncbi.nlm.nih.gov/pubmed/25089661
58. Oyoshi MK, Beaupre J, Venturelli N, Lewis CN, Iwakura Y, Geha RS. "Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus." Journal of Allergy and Clinical Immunology. 2015 Jan. [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/25649082
59. Hoff, S. Oyoshi MK, Macpherson A, Geha RS. "The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flg(ft/ft) mice." 2015 Feb;156(2): 128-130. PMCID - In Process. http://www.ncbi.nlm.nih.gov/pubmed/25499749
60. Merriman JA, Klingelhutz AJ, Diekema DJ, Leung DYM, Schlievert PM. “Novel staphylococcus aureus secreted protein alters keratinocyte proliferation and elicits a pro-inflammatory response in vitro and in vivo.” Biochemistry. Epub 2015 Jul 15. PMID: 26177220 http://www.ncbi.nlm.nih.gov/pubmed/26177220
61. Gao L, Bin L, Rafaels NM, Huang L, Potee J, Ruczinski I, Beaty TH, Paller AS, Schneider LC, Gallo R, Hanifin JM, Beck ALA, Geha RS, Mathias RA, Barnes KC and Leung DYM. “Targeted Deep Sequencing Identifies Rare ‘loss-of-function’ Variants in IFNGR1 for Risk 1 of Atopic Dermatitis Complicated by Eczema Herpeticum.” Journal of Allergy and Clinical Immunology. 2015 Dec: 136(6): 1591-1600. [Epub ahead of print].http://www.ncbi.nlm.nih.gov/pubmed/26343451
62. Li S, Ganguli-Indra G, Indra AK. “Lipidomics analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans.” Expert Rev Proteomics. 2016 May;13(5):451-6. PMCID: PMC4939172. https://www.ncbi.nlm.nih.gov/pubmed/27121756
63. Oyoshi MK, Venturelli N, Geha RS. “Thymic stromal lymphopoietin and interleukin-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis.” Journal of Allergy and Clinical Immunology. 2016 Jul: 138(1):283-6. PMCID: PMC4931957. http://www.ncbi.nlm.nih.gov/pubmed/26830114
64. Leung DY. “Clinical Impilcations of new mechanistic insights into atopid dermatitis.: Curr Opin Pediatr. 2016 Aug;28(4):456-62. https://www.ncbi.nlm.nih.gov/pubmed/27191525
65. Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS. “IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization” J Exp Med. 2016 Sep 19;213(10):2147-66. PMCID: 5032726. https://www.ncbi.nlm.nih.gov/pubmed/27551155
66. Malhotra N, Yoon J, Leyva-Castillo JM, Galand C, Archer N, Miller LS, Geha RS. “IL-22 derived from γδ T cells restricts Staphylococcus aureus infection of mechanically injured skin.” Journal of Allergy and Clinical Immunology. 2016 Oct: 138(4): 1098-1107. PMCID: PMC5056816. https://www.ncbi.nlm.nih.gov/pubmed/27543072
67. Shi B, Bangayan NJ, Curd E, Taylor PA, Gallo RL, Leung DYM, Li H. “The skin microbiome is different in pediatric versus adult atopic dermatitis.” Journal of Allergy and Clinical Immunology. 2016 Oct: 138(4): 1233-1236. PMCID: PMC5235385. https://www.ncbi.nlm.nih.gov/pubmed/27474122
68. Nakatsuji T, Hata T, Chun K, Two A, Chen T, Narala S, Kotol P, Wong C, Trzoss L, Sang-Jip N, Bouslimani A, Melnik A, Latif H, Lockhart A, Artis K, David G, Taylor P, Strieb J, Dorrestein P, Otto M, Zengler K, Fenical W, Leung DYM, Gallo RL. “Staphylococcus aureus exploits barrier defects in atopic dermatitis to trigger cytokine expression.” Journal of Investigative Dermatology. 2016 Nov: 136(11): 2192-2200. PMCID: PMC5103312. https://www.ncbi.nlm.nih.gov/pubmed/27381887
69. Merriman JA, Mueller EA, Cahill MP, Beck LA, Paller AS, Hanifin JM, Ong PY, Schneider L, Babineau DC, David G, Lockhart A, Artis K, Leung DY, Schlievert PM. “Temporal and Racial Differences Associated with Atopic Dermatitis Staphylococcus aureus and Encoded Virulence 13Mar2018 ADRN Publications Page 8 of 16 Factors.” mSphere. 2016 Dec: 1(6). PMCID: PMC5143412. https://www.ncbi.nlm.nih.gov/pubmed/27981233
70. Nakatsuji T, Hata T, Two A, Chun K, Kotol P, Bouslimani A, Latif H, Lockhart A, Artis K, Taylor P, Strieb J, Dorrestein P, Zengler K, Leung DYM, Gallo RL. “Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis.” Sci Transl Med. 2017 Feb: 9(378). PMCID: PMC5600545. https://www.ncbi.nlm.nih.gov/pubmed/28228596
71. Williams MR, Nakatsuji T, Sanford JA, Vrbanac AF, Gall RL. “Staphylococcus aureus induces increased serine protease activity in keratinocytes.” J Invest Dermatol. 2017 Feb: 137(2):377-384. PMCID: PMC5258850. https://www.ncbi.nlm.nih.gov/pubmed/27765722
72. Leung DYM, Jepson B, Beck L, Hanifin J, Schneider L, Paller A, Monti K, David G, Canniff J, Gomez M, Weinberg A. “A clinical trial of intradermal and intramuscular seasonal influenza vaccination in patients with atopic dermatitis.” J Allergy Clin Immunol. 2017 May: 139(5):1575- 1582.e8. https://www.ncbi.nlm.nih.gov/pubmed/28209343
73. Gallo RL. “Human skin is the largest epithelial surface for interaction with microbes.” J Invest Dermatol. 2017 Jun: 137(6):1213-1214. https://www.ncbi.nlm.nih.gov/pubmed/28395897
74. Li S, Villarreal M, Stewart S, Jaewoo C, Indra G, Babineau D, Philpot C, David G, Yoshida T, Boguniewicz M, Hanifin J, Beck L, Leung D, Simpson E, Indra A. “Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in Atopic Dermatitis.” Br J Dermatol. 2017 Oct: 177(4):e125-e127. PMCID: PMC5573657. https://www.ncbi.nlm.nih.gov/pubmed/28244066
75. Williams MR, Nakatsuji T, Gallo RL. “Staphylococcus aureus: Master manipulator of the skin.” Cell Host Microbe. 2017 Nov: 22(5)579-581. https://www.ncbi.nlm.nih.gov/pubmed/29120738
76. Liu H, Archer NK, Dillen CA, Wang Y, Ashbaugh AG, Ortines RV, Kao T, Lee SK, Cai SS, Miller RJ, Marchitto MC, Zhang E, Riggins DP, Plaut RD, Stibitz S, Geha RS, Miller LS. “Staphylococcus aureus epicutaneous exposure drives skin inflammation via IL-36-induced IL-27-mediated T cell responses.” Cell Host Microbe. 2017 Nov: 22(5):653-666.e5. https://www.ncbi.nlm.nih.gov/pubmed/29120743
77. Williams MR, Gallo RL. “Evidence that human skin microbiome dysbiosis promotes atopic dermatitis.” J Invest Dermatol. 2017 Dec: 137(12):2460-2461. https://www.ncbi.nlm.nih.gov/pubmed/29169458
78. Dyjack N, Rios C, Kim BE, Bin L, Taylor P, Bronchick C, Hall CF, Richers BN, Seibold MA, Leung DY. “Minimally invasive skin tape strip RNA-seq identifies novel characteristics of type 2-high atopic dermatitis disease endotype.” J Allergy Clin Immunol. 2018 Jan 6. ePub ahead of print. https://www.ncbi.nlm.nih.gov/pubmed/29309794 13Mar2018 ADRN Publications Page 9 of 16
79. Bin L, Li X, Richers B, Taylor P, Leung DYM. “Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: a potential role in eczema herpeticum.” J Allergy Clin Immunol. 2018 Jan 31. ePub ahead of print. https://www.ncbi.nlm.nih.gov/pubmed/29371118
80. Shi B, Leung DYM, Taylor PA, Li H. “MRSA colonization is associated with decreased skin commensal bacteria in atopic dermatitis.” J Invest Dermatol. 2018 Feb 2. ePub ahead of print. https://www.ncbi.nlm.nih.gov/pubmed/29410379
81. Berdyshev E, Goleva E, Bronova I, Dyjack N, Rios C, Jung J, Taylor P, Jeong M, Hall CF, Richers BN, Norquest KA, Zheng T, Seibold MA, Leung DY. “Lipid abnormalities in atopic skin are driven by type 2 cytokines.” JCI Insight. 2018 Feb 22: 3(4). https://www.ncbi.nlm.nih.gov/pubmed/29467325
82. Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O’Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS. “RORα-expressing T regulatory cells restrain allergic skin inflammation.” Sci Immunol. 2018 Mar 2: 3(21). https://www.ncbi.nlm.nih.gov/pubmed/29500225
83. Simpson EL, Villarreal M, Jepson B, Rafaels N, David G, Hanifin J, Taylor P, Boguniewicz M, Schlievert P, Yoshida T, De Benedetto A, Barnes KC, Leung DYM, Beck LA. “Adult atopic dermatitis colonized with Staphylococcus aureus is associated with a distinct phenotype and endotype.” Accepted by J Invest Dermatol. 2018 Mar 9.
84. Archer NK, Lee SK, Jo J, Kim D, Ortines RV, Wang Y, Marchitto MC, Ravipati A, Cai SS, Dillen CA, Liu H, Miller RJ, Ashbaugh AG, Uppal AS, Oyoshi M, Malhotra N, Hoff S, Garza LA, Kong HH, Segre JA, Geha RS, Miller LS. “Aberrantly activated keratinocyte nuclear IL-1α release drives chronic skin inflammation.” Approved by the ADRN Publications Committee. Revising for JACI February 2018.
85. Leyva-Castillo JM, Yoon J, Geha RS. “IL-22 promotes allergic airway inflammation in epicutaneously sensitized mice.” Approved by the ADRN Publications Committee.
86. Boorgula MP, Taub MA, Rafaels N, Daya M, Chavan S, Shetty A, Cheadle C, Barkataki S, Fan J, David G, Beaty TH, Ruczinski I, Hanifin J, Schneider LC, Gallo R, Paller AS, Beck LA, Leung DY, Mathias RA, Barnes KC. “Methylation changes associated with eczema Herpeticum and allergic response.” Approved by the ADRN Publications Committee