Multisystem-Inflammatory Syndrome in Children (MIS-C) Make an Appointment Find a Doctor Ask a Question Reviewed by Donald Y M Leung, PhD, MD, Pamela L. Zeitlin, MD, MPhil, PhD (May 26, 2020) COVID-19 has mostly affected adults, but doctors around the country are reporting that some children who previously had COVID-19 are experiencing inflammation in the skin, eyes, blood vessels or heart. This new syndrome has been named Multisystem-Inflammatory Syndrome in Children (MIS-C), formerly referred to as pediatric inflammatory multisystem syndrome, or PIMS. It is rare and does not seem to be affecting a large number of children. MIS-C has signs and symptoms similar to other inflammatory conditions, including Kawasaki disease, staphylococcal and streptococcal toxic shock syndromes, bacterial sepsis and macrophage activation syndromes. MIS-C Can Cause Toxic shock with very low blood pressure Breathing difficulties Problems with blood circulating oxygen and nutrients throughout the body Is Multisystem-Inflammatory Syndrome in Children Contagious? Unlike COVID-19, MIS-C does not appear to be contagious. Programs & Services Thousands of patients come to us from around the world to team with our expert physicians and researchers and seek treatment for respiratory, cardiac, immune and related conditions. Search our treatment programs. Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.