Multisystem-Inflammatory Syndrome in Children (MIS-C) Make an Appointment Find a Doctor Ask a Question Reviewed by Donald Y M Leung, PhD, MD, Pamela L. Zeitlin, MD, MPhil, PhD (May 26, 2020) COVID-19 has mostly affected adults, but doctors around the country are reporting that some children who previously had COVID-19 are experiencing inflammation in the skin, eyes, blood vessels or heart. This new syndrome has been named Multisystem-Inflammatory Syndrome in Children (MIS-C), formerly referred to as pediatric inflammatory multisystem syndrome, or PIMS. It is rare and does not seem to be affecting a large number of children. MIS-C has signs and symptoms similar to other inflammatory conditions, including Kawasaki disease, staphylococcal and streptococcal toxic shock syndromes, bacterial sepsis and macrophage activation syndromes. MIS-C Can Cause Toxic shock with very low blood pressure Breathing difficulties Problems with blood circulating oxygen and nutrients throughout the body Is Multisystem-Inflammatory Syndrome in Children Contagious? Unlike COVID-19, MIS-C does not appear to be contagious. Programs & Services Acute Respiratory Clinic (Pediatric) Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.