LAM: Associated Conditions Make an Appointment Refer a Patient Ask a Question Reviewed by National Heart Lung and Blood Institute. (July 01, 2009) Lymphangioleiomyomatosis, or LAM, can also occur in women who have a rare disease called tuberous sclerosis complex (TSC). Women who have TSC often have a milder form of LAM. About 6 out of 10 women who have LAM develop pneumothorax, or a collapsed lung. In this condition, air leaks out of a lung and into the space between the lung and the chest wall. This condition can cause pain and shortness of breath. Sometimes one lung will collapse over and over again. Pneumothorax is a serious condition that usually requires treatment and can sometimes be life threatening. Many women who have LAM get tumors called angiomyolipomas, or AMLs, in their kidneys. Women who have LAM also may develop: Growths in other organs, including the liver and brain. Large tumors in their lymph nodes. A buildup of fluid in their chests, abdomens, or pelvic areas. LAM: Lifestyle Management Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.