Metal Hypersensitivity Make an Appointment Refer a Patient Ask a Question Make an Appointment Refer a Patient Ask a Question Diagnosing Metal Hypersensitivity: Lymphocyte Proliferation Testing Metal hypersensitivity is a cell-mediated immune response that can lead to various diseases, including the granulomatous lung disease called Chronic Beryllium Disease. Hypersensitivity to metals also is increasingly recognized as one of the causes of joint replacement failure. More Than Two Decades of Experience National Jewish Health® Advanced Diagnostic Laboratories has more than two decades of experience in developing and performing Lymphocyte Proliferation Tests (LPT) to measure cell-mediated immune response to metals. Developed the first diagnostic blood test for beryllium sensitization called the Beryllium Lymphocyte Proliferation Test (BeLPT) in the 1990s Performs more than 12,000 BeLPTs annually and is the leading beryllium sensitization testing laboratory in the United States Introduced a nickel lymphocyte proliferation test (NiLPT) to detect nickel sensitization in 2012 Our hypersensitivity assays are developed collaboratively with National Jewish Health physicians, supported by research publications and performed in our CLIA-certified lab. Lymphocyte Proliferation Test: Marker of Antigen Specific T cell Reaction The lymphocyte proliferation test (LPT) is an in vitro test that measures the antigen-specific T cell response to a suspected antigen or metal in culture. LPTs can be performed alone or in conjunction with skin patch testing to demonstrate allergic or hypersensitivity responses. Metal Hypersensitivity Diagnostic Tests Beryllium lymphocyte proliferation test (BeLPT) Nickel lymphocyte proliferation test (NiLPT) View Advanced Diagnostic Labs Test Catalog Metal Hypersensitivity Testing Services Custom lymphocyte proliferation assay development and validation Request Information Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials. Reasons to Choose National Jewish Health The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses Ranked as one of the top two hospitals in pulmonology every year since U.S. News & World Report included this category in its annual “Best Hospitals” survey Ranked in the top 1 percent of hospitals in the nation by HCAHPS Physicians consistently recognized among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly Among the top 6 percent of organizations funded for research by the NIH, providing patients access to more than 300 active clinical trials 121-year history of focus on care, research and education serving thousands of patients with lung, heart, immune and related disorders Make an Appointment We Are Open and Here for You × Our specialty care clinics for adults and children are open and ready to serve you. Your health is important, and that means taking care of your existing health care issues. To make an appointment, call 303.398.1355 or make an appointment online. Patient Safety As we schedule appointments, including necessary procedures, we're taking every precaution to ensure your safety. All staff and providers are required to wear masks and other personal protective equipment, and our facilities are continually cleaned using enhanced sterilization procedures. As best practice for all patients, COVID-19 patients are cared for in separate, dedicated units. Patients and visitors are screened upon arrival and are required to wear masks. Patients may have only one visitor accompany them to appointments. Please bring your own face mask to wear (cannot be a bandana or scarf, but can be a cloth mask). Expanded COVID-19 Testing and Care Available Testing and care for adults and children who may currently have or are recovering from COVID-19 is available. COVID-19 Testing, Care & Resources Close
Reasons to Choose National Jewish Health The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses Ranked as one of the top two hospitals in pulmonology every year since U.S. News & World Report included this category in its annual “Best Hospitals” survey Ranked in the top 1 percent of hospitals in the nation by HCAHPS Physicians consistently recognized among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly Among the top 6 percent of organizations funded for research by the NIH, providing patients access to more than 300 active clinical trials 121-year history of focus on care, research and education serving thousands of patients with lung, heart, immune and related disorders Make an Appointment