Metal Hypersensitivity Make an Appointment Refer a Patient Ask a Question Make an Appointment Refer a Patient Ask a Question Diagnosing Metal Hypersensitivity: Lymphocyte Proliferation Testing Metal hypersensitivity is a cell-mediated immune response that can lead to various diseases, including the granulomatous lung disease called Chronic Beryllium Disease. Hypersensitivity to metals also is increasingly recognized as one of the causes of joint replacement failure. More Than Two Decades of Experience National Jewish Health® Advanced Diagnostic Laboratories has more than two decades of experience in developing and performing Lymphocyte Proliferation Tests (LPT) to measure cell-mediated immune response to metals. Developed the first diagnostic blood test for beryllium sensitization called the Beryllium Lymphocyte Proliferation Test (BeLPT) in the 1990s Performs more than 12,000 BeLPTs annually and is the leading beryllium sensitization testing laboratory in the United States Introduced a nickel lymphocyte proliferation test (NiLPT) to detect nickel sensitization in 2012 Our hypersensitivity assays are developed collaboratively with National Jewish Health physicians, supported by research publications and performed in our CLIA-certified lab. Lymphocyte Proliferation Test: Marker of Antigen Specific T cell Reaction The lymphocyte proliferation test (LPT) is an in vitro test that measures the antigen-specific T cell response to a suspected antigen or metal in culture. LPTs can be performed alone or in conjunction with skin patch testing to demonstrate allergic or hypersensitivity responses. Metal Hypersensitivity Diagnostic Tests Beryllium lymphocyte proliferation test (BeLPT) Nickel lymphocyte proliferation test (NiLPT) View Advanced Diagnostic Labs Test Catalog Metal Hypersensitivity Testing Services Custom lymphocyte proliferation assay development and validation Request Information Clinical Trials For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials. Reasons to Choose National Jewish Health The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses Ranked as one of the top two hospitals in pulmonology every year since U.S. News & World Report included this category in its annual “Best Hospitals” survey Ranked in the top 1 percent of hospitals in the nation by HCAHPS Physicians consistently recognized among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly Among the top 6 percent of organizations funded for research by the NIH, providing patients access to more than 300 active clinical trials 121-year history of focus on care, research and education serving thousands of patients with lung, heart, immune and related disorders Make an Appointment × Safely Get the Care You Need We are ready to help you stay healthy with many same-day appointments available and are taking every precaution to ensure your safety. To make an appointment, call 303.398.1355 or schedule online today. COVID-19 Testing and Care Swab (PCR) and Antibody testing appointments can be booked online and are available with results in 24-48 hours. If you are experiencing symptoms, we have same-day appointments in our adult and pediatric COVID-19 treatment clinics in dedicated areas. We also offer care for those who have had COVID-19 in our Center for Post-COVID-19 Care and Recovery. Learn more about our specialized COVID-19 care. Vaccine Information The vaccine has arrived and we are working through Colorado’s state-guided phases of vaccination. Visit our COVID-19 Vaccines page for more information on timing and availability. Close
Reasons to Choose National Jewish Health The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses Ranked as one of the top two hospitals in pulmonology every year since U.S. News & World Report included this category in its annual “Best Hospitals” survey Ranked in the top 1 percent of hospitals in the nation by HCAHPS Physicians consistently recognized among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly Among the top 6 percent of organizations funded for research by the NIH, providing patients access to more than 300 active clinical trials 121-year history of focus on care, research and education serving thousands of patients with lung, heart, immune and related disorders Make an Appointment