Investigational Treatment for PH-ILD

Trial Objectives

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High blood pressure in the lungs, called pulmonary hypertension (PH), can happen in people with interstitial lung disease (ILD). When these two conditions occur together, it is known as PH-ILD.

There are inhaled treatments for PH-ILD, called treprostinil, that can improve exercise ability. However, it needs to be taken three to five times a day. Researchers are studying an investigative treatment of this medicine, called L606, to see if it is effective and tolerable taken two times a day.

In this study, participants will be randomly assigned to receive either L606 or a placebo (a treatment with no active medicine). During clinic visits, participants will complete walking tests, have heart and lung scans  such as echocardiograms and CT scans, undergo a right heart catheterization to measure the pressure inside their lungs , and provide blood samples.

Researchers will use the information collected to find out whether L606 works to improve exercise ability and to monitor any possible side effects.