SSB/La, Sjogren's Disease Antibody
Test Code
SSB
Description
SSB (or La) is a 48 kDa protein that combines with RNA. SSB antibodies are found in 5-15% of Systemic Lupus Erythematosus (SLE or lupus) patients and 25% of random Sjogren’s disease patients and in approximately 60% of Sjogren’s disease patients with sicca complex. SSB antibodies are almost always found to occur simultaneously with SSA antibodies.
This assay is intended for the semi-quantitative detection of SSB antibodies in human serum.
The presence of these antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of SLE and related connective tissue diseases, such as Sjogren’s disease.
Collect
Serum separator tube or a plain red top tube.
Pediatric Collection
Minimum volume: 0.5 mL serum
Unacceptable Conditions
Plasma, lipemic, grossly hemolyzed, microbially contaminated specimens, or specimens with visible particulates should not be used.
Storage Transport Temp
Frozen. Send serum Priority Overnight via FedEx and in a well insulated container on dry ice.
Stability
Up to 8 hours ambient or 48 hours refrigerated at 2-8°C. Freeze at or below -20°C for longer storage or shipping.
Performed
Weekly
Methodology
Enzyme-linked immunoabsorbent assay (ELISA)
Turnaround Time
7-9 Business Days
Department
Immunology Lab - Diagnostic
Synonyms
Sjogren’s antibody, La
Study Offerings
RUO
CAP/CLIA
Related Tests
SSA, ANA, ENA, ENA6, Sjogren’s antibody, anti-SSB, anti-SSA (SSAB/SSBB), La
Reference Interval
Negative <20, Weak Positive 20-39, Moderate Positive 40-80, Strong Positive >80 units
CPT Code
86235
New York Approved
No: Run with Waiver
FDA
LDT