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Advanced Diagnostic Laboratories

SC5b-9 Level - Terminal Complement Complex (Urine)


Test Code

SC59U

Description

Complement mediated renal diseases such as C3 glomerulopathy (C3G), atypical hemolytic uremic syndrome (aHUS), lupus nephritis (LN) and immunoglobulin A nephropathy (IgAN) are characterized by dysregulated complement activation and increased complement activation products in urine, including soluble C5b-9 (sC5b-9), a marker of terminal complement activation. 

The sC5b-9 protein levels measured in urine are reported as a ratio to the urine creatinine levels. While sC5b-9 levels are undetectable in urine from healthy individuals, it can be elevated in many inflammatory kidney conditions.