Advanced Diagnostic Laboratories

Myositis 17 Antigen Panel

Test Code

MYOS

Description

Myositis is a disease characterized by inflammation of the muscles and is often associated with severe muscle weakness. The most common forms of myositis are polymyositis and dermatomyositis.

The presence of myositis-specific autoantibodies in patients can often be indicative of disease. This panel assays for myositis-specific and myositis-associated autoantibodies to 17 antigens, including several anti-tRNA synthetase autoantibodies. The panel may be used as an important part of the evaluation in those patients with myositis or select cases of idiopathic interstitial pneumonia. The 17 autoantibody specificities detected with the panel are associated with a range of inflammatory muscle diseases.

Collect

Collect in a plain red top or SST tube.

Pediatric Collection

Minimum volume: 0.1 mL

Storage Transport Temp

Send serum Priority Overnight via FedEx and in a well insulated container frozen on dry ice.

Stability

Frozen at -70°C: 1 year. Serum samples may be stored at +2°C to +8°C for up to 14 days if necessary.

Notes

National Jewish Health Advanced Diagnostic Laboratories offer a Myositis Antigen Panel to aid in the diagnosis of the idiopathic inflammatory myopathies, commonly referred to as myositis. When combined with clinical features, the Myositis Antigen Panel can aid clinicians in making a diagnosis of myositis, polymyositis, dermatomyositis, anti-synthetase syndrome and related conditions. The Myositis Antigen Panel provides a qualitative in vitro assay for human antibodies present in serum of the IgG class to 17 different antigens.

Performed

Monday - Friday

Methodology

Immunoblot

Turnaround Time

2-12 days

Department

Immunology Lab - Diagnostic

Synonyms

Mi-2 alpha, Mi-2 beta, Ku, PM-Scl100, PM-Scl75, Jo-1, SRP, PL-7, PL-12, EJ, OJ, Ro-52, TIF1 gamma, MDA5, NXP2, SAE1, cN-1A

Study Offerings

RUO
CAP/CLIA

Reference Interval

Negative 0-5 Units
Borderline 6-10 Units
Positive 11-50 Units
Strong Positive >50 Units

Interpretation

Antibodies to the antigens are determined by an immunoblot assay. The color developed for each antigen is determined by densitometry and the intensity of the color is proportional to the antibody reactivity. The results are given in arbitrary intensity units.