Advanced Diagnostic Laboratories

Anti-Cyclic Citrullinated Peptide

Test Code

CCP

Description

This assay is intended for the semi-quantitative detection of IgG and IgA anti-CCP3 (Cyclic Citrullinated Peptide 3) antibodies in human serum. The presence of these antibodies when considered in conjunction with clinical findings and other laboratory tests is an aid in the diagnosis of RA including RA diagnosed within 2 years of presentation of symptoms.

Rheumatoid arthritis (RA) is a chronic inflammatory disorder that typically affects the small joints in the hands and feet. Unlike the wear-and-tear damage of osteoarthritis, rheumatoid arthritis affects the lining of the joints, causing a painful swelling that can eventually result in bone erosion and joint deformity. It can also affect other parts of the body such as the skin, eyes, lungs and blood vessels. Unlike osteoarthritis (OA) which is age related and the result of wear and tear on the joints, RA is an autoimmune disease in which the body mistakenly attacks its own tissue, namely the lining around the joint leading to inflammation and swelling and ultimately permanent joint damage. It is one of the most common systemic autoimmune diseases, affecting approximately 0.5% of the world population. Since treatment focuses on controlling symptoms and preventing joint damage, early detection is very important.

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