Immune Response Testing

National Jewish Health® Advanced Diagnostic Laboratories uses a variety of technologies to determine the presence or absence of cell-mediated and antibody-mediated immune responses to drugs, vaccines, toxins and pathogens.

We offer antibody response design, development and validation services to pharmaceutical and biotechnology companies seeking antibody-based measures of efficacy and toxicity for their products, and to laboratories and clinicians seeking antibody-based measures for diagnosis and disease staging.

Advanced Diagnostic Laboratories can utilize human samples and non-human test systems to run your assays.

 

Immune Cell Function

  • ELISpot assays to measure antigen-specific T cell frequency
  • Immunophenotype determination by multicolor flow cytometry
  • Functional cytotoxicity assays for NK and T cells, including ADCC
  • Antigen-specific lymphocyte proliferation assays customized to your needs
  • Basophil activation studies (e.g., allergens or drugs)

 

Antibody Activity

  • Antibody responses to new antigens
  • Measurement of adverse antibody responses, including IgG, IgM and IgE

 

Phospho Flow to Measure Kinase Cascade Activity

Inflammatory Response

  • Cytokine measurement: serum, plasma, sputum and intracellular Toll-like receptor (TLR) functional assays

Complement Activation and Inhibition

  • Complement activation products: C3a, C4a, C5a, Bb, SC5b-9, as well as iC3b and C4d
  • In vitro evaluation of the complement activating potential of new compounds, biomaterials of other substances
  • Measurement of autoantibodies against complement components
  • Complement functional screens and comprehensive assays for component function and concentration



Clinical Trials

For more than 100 years, National Jewish Health has been committed to finding new treatments and cures for diseases. Search our clinical trials.

Reasons to Choose National Jewish Health

  • The leading respiratory hospital in the nation and the only one devoted fully to the treatment of respiratory and related illnesses
  • Ranked #1 or #2 in Pulmonology by U.S. News & World Report for 26 consecutive years
  • Ranked in the top 5% of hospitals in the nation by HCAHPS
  • Physicians consistently recognized among the best in the nation by multiple services, including Best Doctors in America and Castle Connolly
  • Among the top 6% of organizations funded for research by the NIH, providing patients access to hundreds of active clinical trials
  • 124-year history of focus on care, research and education serving patients from around the world with lung, heart, immune and related disorders
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