The Redente laboratory focuses on the development and resolution of pulmonary fibrosis. We use cutting edge genetic mouse models and clinical samples to answer or questions. Our questions right now are focused on: 1) Fibroblast persistence and the role of Bcl-2 induced apoptosis in the resolution of established pulmonary fibrosis with the goal to investigate the mechanisms by which inducing to apoptosis can act as the basis for translational application of this work. 2) The role of collagen degradation during fibrosis resolution through the matrix metalloproteinase MMP-9. 3) The role of macrophage lipid mishandling as an initiator of lung injury and pulmonary fibrosis and 4) In collaboration with investigators at National Jewish and the University of Colorado we are investigating the role of Muc5B mis-expression and how this leads to altered epithelial cell and fibroblast communication to drive pulmonary fibrosis.
We seek to complete this research in an inclusive, supportive and positive work and training environment. Fantastic science is our goal and we can get there through collaboration and thinking outside the box!
Lab Resources and Services
Dr. Redente’s laboratory is located in Smith building on National Jewish Health’s campus and offers several unique research methods and animal models for pulmonary basic science and translational research.
Current research projects and grant support
Elizabeth F. Redente, PhD