Tech ID: 00-14
Calcitonin gene-related peptide (CGRP) is a sensory neuropeptide which expression is reduced after allergen challenge in sensitized mice. The same mice develop eosinophilic airway inflammation and airway hyperresponsiveness (AHR). Scientists at National Jewish Health have shown that administration of CGRP to sensitized and challenged mice resulted in the normalization of AHR.
Treatment of AHR
State of Development
Administration of CGRP to sensitized and challenged mice resulted in the normalization of AHR.
This potential therapy for AHR was tested in phase II of clinical trials however the trial was never completed.
Kajekar, Radhika, and Allen C. Myers. "Calcitonin Gene-related Peptide Affects Synaptic and Membrane Properties of Bronchial Parasympathetic Neurons." Respiratory Physiology & Neurobiology 160.1 (2008): 28-36. Print. PMID: 17884737.
Dakhama, A. "Alteration of Airway Neuropeptide Expression and Development of Airway Hyperresponsiveness following Respiratory Syncytial Virus Infection." AJP: Lung Cellular and Molecular Physiology 288.4 (2004): L761-770. Print. PMID: 15608150.
Dakhama, Azzeddine, Arihiko Kanehiro, Mika J. Mäkelä, Joan E. Loader, Gary L. Larsen, and Erwin W. Gelfand. "Regulation of Airway Hyperresponsiveness by Calcitonin Gene-related Peptide in Allergen Sensitized and Challenged Mice." American Journal of Respiratory and Critical Care Medicine 165.8 (2002): 1137-144. Print. PMID: 11956058.
Erwin Gelfand, MD, Azzedine Dakhama, PhD (National Jewish Health) and Alain Cadieux, PhD (Universite de Sherbrooke)
Issued US patent #6,743,429 and International Patent Application publication #WO/2001/068118: pending in Canada and Europe, and issued in Australia (#2001249207).
The IP is owned by the National Jewish Health and the Universite de Sherbrooke.
Available for licensing.
For Further Information, Contact:
Emmanuel Hilaire, PhD
Technology Transfer Office
National Jewish Health
1400 Jackson Street, Room M206b
Denver, CO 80206