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Figure 1

Figure 1. In the area of genetic variation, we are using next generation sequencing and genotyping to identify polymorphisms in genomic sequences. In one project, we are sequencing whole genomes from clinically relevant pathogenic micro-organisms to identify single nucleotide polymorphisms (snps), insertions and deletions, genomic duplications, and genomic rearrangements that may contribute to phenotypic traits ranging from increased virulence to drug resistance. In another project, we are resequencing targeted areas of the genome in a large cohort of asthmatic subjects to identify rare variants that explain their varied response to a common asthma medication.