Rose Laboratory

Current Projects

  1. My early publications focused on antigen exposure characterization and outbreak investigations of hypersensitivity pneumonitis. I developed and led a multi-disciplinary program involving physicians, industrial hygienists, epidemiologists and microbiologists. I described the first reported outbreak of “lifeguard lung”, and was a leader in creating the program in noninfectious granulomatous pneumonitis at National Jewish Health. I was co-investigator on an NIH-funded multi-center study investigating the causes and describing clinical phenotypes of sarcoidosis.

  2. Since 2003, I have had federal funding for programs focused on cardiopulmonary diseases in western miners and historic uranium industry workers. As Principal Investigator and Medical Director of the Miners Clinic, I have developed a program of clinical care and research that has led to a number of scientific publications. Our recent work implicates exposure to respirable silica and silicates in increased prevalence and severity of Coal Worker’s Pneumoconiosis and progressive massive fibrosis (PMF), as well as newly recognized accelerated silicosis in stone fabricators.

  3. In 2009, I created the Colorado-based clinical research program on deployment-related lung diseases. I developed collaborations with military and academic scientists and physicians including in the Department of Defense (DOD), the Veterans Administration, the U.S. Geological Survey, and laboratory-based scientists at National Jewish Health. I was principal investigator on a DOD-funded study to examine lung histologic profiles of symptomatic Iraq and Afghanistan deployers. In 2016, our multi-disciplinary group of investigators obtained DOD funding for a 5-year multi-project study to explore mechanisms and treatment of deployment-related epithelial lung injury. I am a Project Lead/PI, on “Exposure Characterization and Identification of Noninvasive Methods for Diagnosis of Deployment-Related Lung Disease”, that expands our research on exposure and disease characterization, Lung Clearance Index testing, and quantitative chest CT analysis.  I was co-investigator on a study exploring the role of matrix metalloproteinases in lung injury and fibrosis from exposure to silicate-containing dusts.  I served on the National Academy of Sciences, Engineering and Medicine (NAS) committee on The Assessment of the Dept. of Veterans Affairs Airborne Hazards and Open Burn Pit Registry. I am a current member the NAS Committee on the Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations.