Current Projects and Grant Support

U10 HL74073 (PI: Richard J. Martin)    



Asthma Clinical Research Network II     

The major goal of this multicenter grant is to evaluate standard and new therapies for asthma.

U10 HL098075 (PI: Richard J. Martin) 



Clinical Centers for the NHLBI Asthma Network (AsthmaNet)

The major goal of this project is to investigate and validate new and standard therapies in asthma.

PO1 HL36577 (PI: Gelfand E)      



Inflammation, Airways Reactivity and Asthma

This Program Project Grant focuses on the inflammatory response in asthma and its effect on airways reactivity. 

Role: PI (of prior projects and of present clinical core)

RO1 AI070175 (PI: Chu, H.W.)

09/01/08 – 8/31/12


Effects of Allergic Inflammation on TLR2 Signaling and Mycoplasma Infection

The major goals of this project are to determine the role of allergic inflammation in TLR2 signaling of airway epithelial cells and dendritic cells in response to mycoplasma infection, and to determine the impact of low level of bacterial infection on Th2 differentiation of T cells through modulation of dendritic cells.

Role: Co-PI

1R01 HL088264 (PI: Chu, H.W.)

12/10/08 – 11/30/12 


SPLUNC1 Protein in Host Defense against Mycoplasma pneumoniae Infection

The major goal is to study the function and regulation of SPLUNC1 protein against bacterial (i.e., Mycoplasma pneumoniae) infection in the context of an airway Th2 cytokine milieu.

Role: Co-PI

Research Grant (PI: Chu, H.W.)

7/1/08 – 6/30/11

Flight Attendant Medical Research Institute (FAMRI)

Host Defense Functions of Airway Epithelial Cells in COPD

The overall objective of this study is to determine the molecular mechanisms responsible for impaired airway epithelial defense against bacteria in patients with chronic obstructive pulmonary disease (COPD). Specifically, the role of prostaglandin E2 (PGE2) pathway in the context of cigarette smoke exposure will be studied in brushed bronchial epithelial cells from COPD patients and control subjects.

Role: Co-PI

1P30HL101294 (PI: Richard J. Martin) 


Fostering Collaborations and the Career of a Newly Recruited Pulmonary Scientist

This project will support establishing a fully equipped laboratory for the newly independent investigator to conduct research on glucocorticoid signaling and lung disease. Integration of the newly independent investigator within existing programs at NJH and the formation of collaborations are key secondary goals of the project. Human brushed bronchial epithelial cells from COPD patients and control subjects.

HS2639 (PI: Richard J. Martion)

1/2012 – 12/2013


Identification of Molecular Biomarkers to Stratify Patients with Refractory Asthma

Severe, refractory (uncontrolled) asthma may be driven by pathogenic mechanisms, including tissue eosinophilia, subacute bacterial infection, gastroesophageal reflux and other unknown processes. Invasive methods are generally available to identify these drivers of disease on a patient by patient basis. Presently the only method to truly direct personalized therapy is by bronchoscopy with lavage, biopsy, and brushing information. The purpose of this study is to identify blood biomarkers that are patients with disease that is not controlled by current therapies.