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Our lab uses our expertise in endothelial cell biology and sphingolipid signaling to better understand the complex mechanisms behind COPD and Emphysema caused by environmental exposures to cigarette smoke, vaping, and respiratory viruses such as SARS-CoV-2. Follow on
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Petrache Lab
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Current Research
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Specialized Techniques:
Immunofluorescence Microscopy
Immunocytochemistry
Immunofluorescence Experiments
Lung Dynamics and Morphometry
Electric Cell substrate Impedance Sensing (ECIS)
Endothelial cell isolation from lung biopsy
Ingenuity Pathway Analyses (IPA)
In vivo and in vitro E-Cigarette and Cigarette Smoke exposure models
Specialized Equipment:
Echo Revolution Microscope
Nikon Eclipse 80i Microscope
Nikon Eclipse Ti-U Microscope
Vitrocell VCl Smoke Delivery System
ECIS (Z Theta and TEER24)
Affymetrix Genechip System
Training Opportunities:
Understand lung cell biology and lung disease models
Analyze mechanisms leading to lung injury
Investigate treatment strategies for Covid-19
Use models to study in vivo and in vitro lung disease
Recreate molecular diseases, pathways, and networks using pathway analysis software